Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept

被引：359

作者：

Chung, Hae Young ^{[1
]}

Kim, Dae Hyun ^{[1
]}

Lee, Eun Kyeong ^{[1
,2
]}

Chung, Ki Wung ^{[1
]}

Chung, Sangwoon ^{[3
]}

Lee, Bonggi ^{[4
]}

Seo, Arnold Y. ^{[5
]}

Chung, Jae Heun ^{[6
]}

Jung, Young Suk ^{[1
]}

Im, Eunok ^{[1
]}

Lee, Jaewon ^{[1
]}

Kim, Nam Deuk ^{[1
]}

Choi, Yeon Ja ^{[7
]}

Im, Dong Soon ^{[1
]}

Yu, Byung Pal ^{[1
,8
]}

机构：

[1] Pusan Natl Univ, Dept Pharm, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea

[2] Korea Inst Toxicol, Pathol & Analyt Ctr, Daejeon 34114, South Korea

[3] Ohio State Univ, Dept Internal Med Pulm Allergy Crit Care & Sleep, Columbus, OH 43210 USA

[4] Korea Inst Oriental Med KIOM, Korean Med KM Applicat Ctr, Daegu 41062, South Korea

[5] Howard Hughes Med Inst, Janelia Res Campus, Ashburn, VA 20147 USA

[6] Pusan Natl Univ, Dept Internal Med, Yangsan Hosp, Yangsan 50612, South Korea

[7] Dongguk Univ, Div Chem & Biotechnol, Dept Biopharmaceut Engn, Gyeongju 38066, South Korea

[8] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA

来源：

AGING AND DISEASE | 2019年 / 10卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

chronic inflammation; senoinflammation; aging; senescence-associated secretome; inflammasome; age-related diseases; NF-KAPPA-B; GLYCATION END-PRODUCTS; ENDOPLASMIC-RETICULUM STRESS; NLRP3; INFLAMMASOME; CYTOKINE PRODUCTION; GENE-EXPRESSION; T-CELLS; RECEPTOR; OBESITY; MICRORNAS;

D O I：

10.14336/AD.2018.0324

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. Currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. However, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. A more comprehensive view of age-related inflammation, that has a scope beyond the conventional view, is therefore required. In this review, we discuss newly emerging data on multi-phase inflammatory networks and proinflammatory pathways as they relate to aging. We describe the age-related upregulation of nuclear factor (NF)-kappa B signaling, cytokines/chemokines, endoplasmic reticulum (ER) stress, inflammasome, and lipid accumulation. The later sections of this review present our expanded view of age-related senescent inflammation, a process we term "senoinflammation", that we propose here as a novel concept. As described in the discussion, senoinflammation provides a schema highlighting the important and ever-increasing roles of proinflammatory senescence-associated secretome, inflammasome, ER stress, TLRs, and microRNAs, which support the senoinflammation concept. It is hoped that this new concept of senoinflammation opens wider and deeper avenues for basic inflammation research and provides new insights into the anti-inflammatory therapeutic strategies targeting the multiple proinflammatory pathways and mediators and mediators that underlie the pathophysiological aging process.

引用

页码：367 / 382

页数：16

共 150 条

[1] Motif module map reveals enforcement of aging by continual NF-κB activity [J].