Pd(II) supramolecular cage-catalyzed successive oxidative coupling: One-pot and regioselective synthesis of functionalized carbazoles from indoles

被引：3
|
作者：
Wu, Xi-Ren [1 ,2 ]
Peng, He-Long [1 ]
Wei, Lian-Qiang [1 ]
Li, Li-Ping [1 ]
Yao, Su-Yang [1 ]
Ye, Bao-Hui [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China
[2] Guangdong Med Univ, Sch Pharm, Dongguan 523808, Peoples R China
来源：
CATALYSIS COMMUNICATIONS | 2019年 / 124卷
基金：
中国国家自然科学基金;
关键词：
Carbazole; Indole; Oxidative Heck reaction; Pd(II) supramolecular cage; C-H functionalization; ALKENYLATION; BENZANNULATION; EFFICIENT; ARENES;
D O I：
10.1016/j.catcom.2019.02.023
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Carbazole is an important compound in pharmaceuticals and functional materials. A new Pd(II) supramolecular cage-catalyzed protocol for the synthesis of multifunctional carbazoles from indoles is described through regioselective successive oxidative Heck reactions. This new protocol is highly efficient, with a low Pd (2.4 mol%) catalyst loading and good compatibility for both N-H free and N-protected indole substrates. Moreover, it can be used to synthesize carbazoles with various functional groups by a one-pot two-step procedure. The excellent catalytic activity can be attributed to the distinct properties of the supramolecular cage structure in uniformly distributive and well-defined Pd(II) active centers on the cage surfaces.
引用
收藏
页码：12 / 18
页数：7
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