Unlocking CNS Cell Type Heterogeneity

被引:14
作者
Emery, Ben [1 ]
Barres, Ben A. [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA
关键词
D O I
10.1016/j.cell.2008.10.031
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A major challenge to understanding how cells work together in the central nervous system (CNS) is the heterogeneous cellular composition of the brain. In this issue, Heiman et al. (2008) and Doyle et al. (2008) introduce a new strategy (TRAP) that enables the profiling of translated mRNAs in specific CNS cell populations without the need for purifying cells to homogeneity.
引用
收藏
页码:596 / 598
页数:4
相关论文
共 8 条
[1]   Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo [J].
Arlotta, P ;
Molyneaux, BJ ;
Chen, J ;
Inoue, J ;
Kominami, R ;
Macklis, JD .
NEURON, 2005, 45 (02) :207-221
[2]   A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function [J].
Cahoy, John D. ;
Emery, Ben ;
Kaushal, Amit ;
Foo, Lynette C. ;
Zamanian, Jennifer L. ;
Christopherson, Karen S. ;
Xing, Yi ;
Lubischer, Jane L. ;
Krieg, Paul A. ;
Krupenko, Sergey A. ;
Thompson, Wesley J. ;
Barres, Ben A. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (01) :264-278
[3]   A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neurons [J].
Dugas, Jason C. ;
Mandemakers, Wim ;
Rogers, Madolyn ;
Ibrahim, Adiljan ;
Daneman, Richard ;
Barres, Ben A. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (33) :8294-8305
[4]   A gene expression atlas of the central nervous system based on bacterial artificial chromosomes [J].
Gong, SC ;
Zheng, C ;
Doughty, ML ;
Losos, K ;
Didkovsky, N ;
Schambra, UB ;
Nowak, NJ ;
Joyner, A ;
Leblanc, G ;
Hatten, ME ;
Heintz, N .
NATURE, 2003, 425 (6961) :917-925
[5]   Gene expression nervous system atlas (GENSAT) [J].
Heintz, N .
NATURE NEUROSCIENCE, 2004, 7 (05) :483-483
[6]   FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains [J].
Lobo, MK ;
Karsten, SL ;
Gray, M ;
Geschwind, DH ;
Yang, XW .
NATURE NEUROSCIENCE, 2006, 9 (03) :443-452
[7]   Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans [J].
Roy, PJ ;
Stuart, JM ;
Lund, J ;
Kim, SK .
NATURE, 2002, 418 (6901) :975-979
[8]   Molecular taxonomy of major neuronal classes in the adult mouse forebrain [J].
Sugino, K ;
Hempel, CM ;
Miller, MN ;
Hattox, AM ;
Shapiro, P ;
Wu, CZ ;
Huang, ZJ ;
Nelson, SB .
NATURE NEUROSCIENCE, 2006, 9 (01) :99-107