Candidate and non-candidate genes in behavior genetics

被引：62

作者：

Flint, Jonathan ^{[1
]}

Munafo, Marcus R. ^{[2
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

[2] Univ Bristol, Sch Expt Psychol, Bristol BS8 1TU, Avon, England

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2013年 / 23卷 / 01期

基金：

英国惠康基金;

关键词：

SEROTONIN TRANSPORTER GENE; STRESSFUL LIFE EVENTS; DE-NOVO MUTATIONS; COMMON VARIANTS; PROMOTER POLYMORPHISM; 5-HTTLPR; DEPRESSION; ASSOCIATION; MODERATION; HIPPOCAMPAL;

D O I：

10.1016/j.conb.2012.07.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this review we discuss recent developments in psychiatric genetics: on the one hand, studies using whole genome approaches (genome-wide association studies (GWAS) and exome sequencing) are coming close to finding genes and molecular variants that contribute to disease susceptibility; on the other candidate genes, such as the serotonin transporter, continue to dominate in genetic studies of brain imaging phenotypes and in protracted searches for gene by environment interactions. These two areas intersect, in that new information about genetic effects from whole genome approaches, should (but does not always) inform the single locus analyses.

引用

页码：57 / 61

页数：5

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