Enantioselective Suzuki reactions: Catalytic asymmetric synthesis of compounds containing quaternary carbon centers

被引：80
|
作者：
Willis, MC [1 ]
Powell, LHW
Claverie, CK
Watson, SJ
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] Novartis Horsham Res Ctr, Horsham RH12 4AB, W Sussex, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 10期
关键词：
asymmetric catalysis; cross-coupling; enantioselectivity; palladium;
D O I：
10.1002/anie.200352648
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Prochiral ditriflates can act as substrates in asymmetric Suzuki couplings by using an enantioselective desymmetrization strategy. The products are obtained with selectivities up to 86% ee and contain a quaternary carbon center and a synthetically useful vinyl triflate functionality (see scheme).
引用
收藏
页码：1249 / 1251
页数：3
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