Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents

被引：15

作者：

Bolelli, Kayhan ^{[1
]}

Yalcin, Ismail ^{[1
]}

Ertan-Bolelli, Tugba ^{[1
]}

Ozgen, Selda ^{[2
]}

Kaynak-Onurdag, Fatma ^{[2
]}

Yildiz, Ilkay ^{[1
]}

Aki, Esin ^{[1
]}

机构：

[1] Ankara Univ, Dept Pharmaceut Chem, Fac Pharm, TR-06100 Ankara, Turkey

[2] Gazi Univ, Dept Pharmaceut Microbiol, Fac Pharm, TR-06330 Ankara, Turkey

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期

关键词：

Benzothiazole; Antibacterial activity; Antifungal activity; Multi-drug resistance; TOPOISOMERASE-II INHIBITORS; ANTITUMOR BENZOTHIAZOLES; BENZIMIDAZOLES; BENZOXAZOLES; DERIVATIVES; 3D-QSAR; ACID;

D O I：

10.1007/s00044-011-9918-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl] benzothiazole derivatives (6a-k) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at minimum inhibitory concentration (MIC) values between 100 and 6.25 mu g/ml. Compounds 6d and 6k exhibited significant antibacterial activity showing 6.25 mu g/ml MIC values against drug-resistant S. aureus and P. aeruginosa isolates, respectively.

引用

页码：3818 / 3825

页数：8

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