Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series

被引:31
|
作者
Droitcourt, Catherine [1 ]
Milpied, Brigitte [1 ]
Ezzedine, Khaled [1 ,2 ]
Hubiche, Thomas [1 ]
Belin, Emilie [1 ]
Akpadjan, Fabrice [1 ]
Taieb, Alain [1 ,2 ]
Seneschal, Julien [1 ,2 ]
机构
[1] Bordeaux Univ Hosp, St Andre & Pellegrin Hosp, Dept Dermatol & Pediat Dermatol, Bordeaux, France
[2] Univ Bordeaux, INSERM, U1035, Bordeaux, France
关键词
Alopecia areata; Methotrexate; Methylprednisolone; TERM-FOLLOW-UP; METHYLPREDNISOLONE THERAPY; ORAL CORTICOSTEROIDS; EFFICACY; UNIVERSALIS; COMBINATION; TOTALIS;
D O I
10.1159/000339341
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: The combination of systemic pulse corticosteroids and methotrexate in the treatment of severe alopecia areata has never been reported. Objective:The objective of this work was to give arguments for the efficacy and safety of this combined treatment. Methods: This was a retrospective case series of patients treated with intravenous 500 mg methylprednisolone per day for 3 consecutive days monthly during 3 months plus methotrexate initiated at the end of the second pulse regimen. We reviewed all case notes of patients who received this regimen between January 1 2007 and December 1 2010. Results: Twenty patients were treated. Data on hair regrowth at month 12 were available for all patients; 14 patients were still receiving the treatment on December 1 2010, 2 patients were lost of follow-up, and 4 patients had stopped the treatment. Of the 14 patients who were still receiving the treatment regimen at month 18, 10 (10/20, 50%) had total hair regrowth and 4 (4/20, 20%) had incomplete but satisfactory hair regrowth. The treatment was well tolerated. Conclusion: The initial treatment by pulse intravenous corticosteroids may influence the overall response. This approach should be evaluated in a larger series of patients. Copyright (c) 2012 S. Karger AG, Basel
引用
收藏
页码:369 / 373
页数:5
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