From the experimental laboratory to the patient: How does it happen?

被引：3
作者：
Baue, AE
机构：
[1] Box 396, Fisher's Island
来源：
SHOCK | 2005年 / 24卷 / 06期
关键词：
potential therapeutic agents; drug studies; animals; therapy; discoveries; US Patent Office; ATP-MgCl2; ethyl pyruvate; clinical use;
D O I：
10.1097/01.shk.0000188327.82641.fe
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Many potential therapeutic agents or drugs are evaluated in experimental animal laboratories, but in spite of interesting effects, they infrequently come into common clinical use. The reasons for this are reviewed. Agents studied previously and many being studied now are cited. Perhaps the biggest benefit of study of drugs in animals (other than for safety and toxicity) is to help us better understand the pathophysiology of disease.
引用
收藏
页码：505 / 507
页数：3
相关论文
共 11 条
[1]  
Baue A E, 1980, Adv Shock Res, V3, P67
[2]  
Chaudry I H, 1980, Adv Shock Res, V3, P27
[3]  
Fink M P, 2004, Minerva Anestesiol, V70, P365
[4]   The old file-drawer problem [J].
Kennedy, D .
SCIENCE, 2004, 305 (5683) :451-451
[5]   Ringer's ethyl pyruvate in hemorrhagic shock and resuscitation does not improve early hemodynamics or tissue energetics [J].
Mulier, KE ;
Beilman, GJ ;
Conroy, MJ ;
Taylor, JH ;
Skarda, DE ;
Hammer, BE .
SHOCK, 2005, 23 (03) :248-252
[6]   Novel strategies for the treatment of sepsis [J].
Riedemann, NC ;
Guo, RF ;
Ward, PA .
NATURE MEDICINE, 2003, 9 (05) :517-524
[7]   Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction [J].
Sappington, PL ;
Fink, ME ;
Yang, RK ;
Delude, RL ;
Fink, MP .
SHOCK, 2003, 20 (06) :521-528
[8]   Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock [J].
Venkataraman, R ;
Kellum, JA ;
Song, M ;
Fink, MP .
SHOCK, 2002, 18 (06) :507-512
[9]   Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis [J].
Yang, RK ;
Uchiyama, T ;
Watkins, SK ;
Han, XN ;
Fink, MP .
SHOCK, 2004, 22 (04) :369-375
[10]   Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis [J].
Yang, RK ;
Uchiyama, T ;
Alber, SM ;
Han, XN ;
Watkins, SK ;
Delude, RL ;
Fink, MP .
CRITICAL CARE MEDICINE, 2004, 32 (07) :1453-1459
12