Immunolocalization of basic fibroblast growth factor in porcine epiphyseal growth plate

被引：9
作者：
Leach, RM [1 ]
Sokol, C [1 ]
McMurtry, JP [1 ]
机构：
[1] AGR RES SERV,USDA,GROWTH BIOL LAB,BELTSVILLE,MD 20705
来源：
DOMESTIC ANIMAL ENDOCRINOLOGY | 1997年 / 14卷 / 02期
关键词：
D O I：
10.1016/S0739-7240(96)00120-8
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Recent evidence clearly indicates that basic fibroblast growth factor (bFGF) signal transduction is essential for normal skeletal development. Here, we report that bFGF and its receptor are specifically localized in the terminal hypertrophic chondrocytes of the porcine epiphyseal growth plate, the tissue responsible for longitudinal bone growth. Similar observations were obtained with the chondrocytes immediately adjacent to resorbing blood vessels in the secondary center of ossification of the epiphysis. These results are consistent with a recent proposal that bFGF functions in coupling osteogenesis with chondrogenesis by attracting the vascular invasion of cartilage from adjacent trabecular bone. (C) Elsevier Science Inc. 1997.
引用
收藏
页码：129 / 132
页数：4
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