The versatile roles and clinical implications of exosomal mRNAs and microRNAs in cancer

被引：8

作者：

Tang, Shuli ^{[1
]}

Yu, Siming ^{[2
]}

Cheng, Jianan ^{[3
]}

Zhang, Yanqiao ^{[1
]}

Huang, Xiaoyi ^{[4
]}

机构：

[1] Harbin Med Univ, Dept Gastrointestinal Med Oncol, Canc Hosp, 150 Haping Rd, Harbin 150001, Heilongjiang, Peoples R China

[2] Peking Univ, Shenzhen Hosp, Drug Clin Trails Inst, Dept Pharm, Shenzhen, Guangdong, Peoples R China

[3] Rhein Westfal TH Aachen, Inst Immunol, Med Fac, Aachen, Germany

[4] Harbin Med Univ, Canc Hosp, Biotherapy Ctr, 150 Haping Rd, Harbin 150001, Heilongjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2020年 / 35卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Exosomes; mRNAs; microRNAs; diagnosis; prognosis; drug resistance; MESENCHYMAL STEM-CELLS; POTENTIAL DIAGNOSTIC BIOMARKERS; METASTATIC NICHE FORMATION; EXTRACELLULAR VESICLES; PROSTATE-CANCER; CIRCULATING EXOSOMES; MULTIVESICULAR BODIES; PROGNOSTIC BIOMARKER; MEMBRANE-VESICLES; TUMOR-GROWTH;

D O I：

10.1177/1724600820920293

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Extracellular vesicles (EVs), which include exosomes, microvesicles, and apoptotic bodies, are nanosized structures that are secreted by various cells and act as important mediators in intercellular communication. Recent studies have shown that exosomes carrying bioactive molecules are generated from multivesicular bodies and are present in various body fluids. mRNAs and microRNAs (miRNAs) are encapsulated in exosomes and have been found to be involved in multiple pathophysiological processes. Here, we provide a review of tumor-associated exosomal mRNAs and miRNAs and their roles in metastasis and drug resistance. In particular, we emphasize their clinical application potential as diagnostic and prognostic biomarkers of cancer and in cancer therapy.

引用

页码：3 / 19

页数：17

共 178 条

[51]

Heiser A, 2002, J CLIN INVEST, V109, P409, DOI 10.1172/JCI14364

[52] Comparative analysis of prostate cancer specific biomarkers PCA3 and ERG in whole urine, urinary sediments and exosomes [J].

Hendriks, Rianne J. ;

Dijkstra, Siebren ;

Jannink, Sander A. ;

Steffens, Martijn G. ;

van Oort, Inge M. ;

Mulders, Peter F. A. ;

Schalken, Jack A. .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2016, 54 (03) :483-492

[53] Human Urinary Exosomes as Innate Immune Effectors [J].

Hiemstra, Thomas F. ;

Charles, Philip D. ;

Gracia, Tannia ;

Hester, Svenja S. ;

Gatto, Laurent ;

Al-Lamki, Rafia ;

Floto, R. Andres ;

Su, Ya ;

Skepper, Jeremy N. ;

Lilley, Kathryn S. ;

Frankl, Fiona E. Karet .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 25 (09) :2017-2027

[54] Tumour exosome integrins determine organotropic metastasis [J].

Hoshino, Ayuko ;

Costa-Silva, Bruno ;

Shen, Tang-Long ;

Rodrigues, Goncalo ;

Hashimoto, Ayako ;

Mark, Milica Tesic ;

Molina, Henrik ;

Kohsaka, Shinji ;

Di Giannatale, Angela ;

Ceder, Sophia ;

Singh, Swarnima ;

Williams, Caitlin ;

Soplop, Nadine ;

Uryu, Kunihiro ;

Pharmer, Lindsay ;

King, Tari ;

Bojmar, Linda ;

Davies, Alexander E. ;

Ararso, Yonathan ;

Zhang, Tuo ;

Zhang, Haiying ;

Hernandez, Jonathan ;

Weiss, Joshua M. ;

Dumont-Cole, Vanessa D. ;

Kramer, Kimberly ;

Wexler, Leonard H. ;

Narendran, Aru ;

Schwartz, Gary K. ;

Healey, John H. ;

Sandstrom, Per ;

Labori, Knut Jorgen ;

Kure, Elin H. ;

Grandgenett, Paul M. ;

Hollingsworth, Michael A. ;

de Sousa, Maria ;

Kaur, Sukhwinder ;

Jain, Maneesh ;

Mallya, Kavita ;

Batra, Surinder K. ;

Jarnagin, William R. ;

Brady, Mary S. ;

Fodstad, Oystein ;

Muller, Volkmar ;

Pantel, Klaus ;

Minn, Andy J. ;

Bissell, Mina J. ;

Garcia, Benjamin A. ;

Kang, Yibin ;

Rajasekhar, Vinagolu K. ;

Ghajar, Cyrus M. .

NATURE, 2015, 527 (7578) :329-+

[55] Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C [J].

Hsu, Chieh ;

Morohashi, Yuichi ;

Yoshimura, Shin-ichiro ;

Manrique-Hoyos, Natalia ;

Jung, SangYong ;

Lauterbach, Marcel A. ;

Bakhti, Mostafa ;

Gronborg, Mads ;

Moebius, Wiebke ;

Rhee, JeongSeop ;

Barr, Francis A. ;

Simons, Mikael .

JOURNAL OF CELL BIOLOGY, 2010, 189 (02) :223-232

[56] A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection [J].

Hu, Jiaming ;

Sheng, Yan ;

Kwak, Kwang Joo ;

Shi, Junfeng ;

Yu, Bohao ;

Lee, L. James .

NATURE COMMUNICATIONS, 2017, 8

[57] Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance [J].

Hu, Y-B ;

Yan, C. ;

Mu, L. ;

Mil, Y-L ;

Zhao, H. ;

Hu, H. ;

Li, X-L ;

Tao, D-D ;

Wu, Y-Q ;

Gong, J-P ;

Qin, J-C .

ONCOGENE, 2019, 38 (11) :1951-1965

[58] Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer [J].

Huang, Xiaoyi ;

Yuan, Tiezheng ;

Liang, Meihua ;

Du, Meijun ;

Xia, Shu ;

Dittmar, Rachel ;

Wang, Dian ;

See, William ;

Costello, Brian A. ;

Quevedo, Fernando ;

Tan, Winston ;

Nandy, Debashis ;

Bevan, Graham H. ;

Longenbach, Sherri ;

Sun, Zhifu ;

Lu, Yan ;

Wang, Tao ;

Thibodeau, Stephen N. ;

Boardman, Lisa ;

Kohli, Manish ;

Wang, Liang .

EUROPEAN UROLOGY, 2015, 67 (01) :33-41

[59] Characterization of human plasma-derived exosomal RNAs by deep sequencing [J].

Huang, Xiaoyi ;

Yuan, Tiezheng ;

Tschannen, Michael ;

Sun, Zhifu ;

Jacob, Howard ;

Du, Meijun ;

Liang, Meihua ;

Dittmar, Rachel L. ;

Liu, Yong ;

Liang, Mingyu ;

Kohli, Manish ;

Thibodeau, Stephen N. ;

Boardman, Lisa ;

Wang, Liang .

BMC GENOMICS, 2013, 14

[60]

Huang ZB, 2017, CANCER EPIDEM BIOMAR, V26, P188, DOI [10.1158/1055-9965.EPI-16-0607, 10.1158/1055-9965.epi-16-0607]

← 1 2 3 4 5 6 7 8 9 10 →