The versatile roles and clinical implications of exosomal mRNAs and microRNAs in cancer

被引：8

作者：

Tang, Shuli ^{[1
]}

Yu, Siming ^{[2
]}

Cheng, Jianan ^{[3
]}

Zhang, Yanqiao ^{[1
]}

Huang, Xiaoyi ^{[4
]}

机构：

[1] Harbin Med Univ, Dept Gastrointestinal Med Oncol, Canc Hosp, 150 Haping Rd, Harbin 150001, Heilongjiang, Peoples R China

[2] Peking Univ, Shenzhen Hosp, Drug Clin Trails Inst, Dept Pharm, Shenzhen, Guangdong, Peoples R China

[3] Rhein Westfal TH Aachen, Inst Immunol, Med Fac, Aachen, Germany

[4] Harbin Med Univ, Canc Hosp, Biotherapy Ctr, 150 Haping Rd, Harbin 150001, Heilongjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2020年 / 35卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Exosomes; mRNAs; microRNAs; diagnosis; prognosis; drug resistance; MESENCHYMAL STEM-CELLS; POTENTIAL DIAGNOSTIC BIOMARKERS; METASTATIC NICHE FORMATION; EXTRACELLULAR VESICLES; PROSTATE-CANCER; CIRCULATING EXOSOMES; MULTIVESICULAR BODIES; PROGNOSTIC BIOMARKER; MEMBRANE-VESICLES; TUMOR-GROWTH;

D O I：

10.1177/1724600820920293

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Extracellular vesicles (EVs), which include exosomes, microvesicles, and apoptotic bodies, are nanosized structures that are secreted by various cells and act as important mediators in intercellular communication. Recent studies have shown that exosomes carrying bioactive molecules are generated from multivesicular bodies and are present in various body fluids. mRNAs and microRNAs (miRNAs) are encapsulated in exosomes and have been found to be involved in multiple pathophysiological processes. Here, we provide a review of tumor-associated exosomal mRNAs and miRNAs and their roles in metastasis and drug resistance. In particular, we emphasize their clinical application potential as diagnostic and prognostic biomarkers of cancer and in cancer therapy.

引用

页码：3 / 19

页数：17

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