RNA editing: Getting U into RNA

被引：47
作者：
Kable, ML
Heidmann, S
Stuart, KD
机构：
[1] UNIV WASHINGTON,DEPT PATHOBIOL,SEATTLE,WA 98195
[2] UNIV BAYREUTH,DEPT GENET,D-95440 BAYREUTH,GERMANY
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 05期
关键词：
D O I：
10.1016/S0968-0004(97)01041-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable of a full round of guide-RNA-directed editing.
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页码：162 / 166
页数：5
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