Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer

被引：2
作者：
Ropponen, KM
Eskelinen, MJ
Lipponen, PK
Alhava, E
Kosma, VM
机构：
[1] KUOPIO UNIV HOSP, DEPT SURG, SF-70210 KUOPIO, FINLAND
[2] KUOPIO UNIV HOSP, DEPT PATHOL, SF-70210 KUOPIO, FINLAND
来源：
JOURNAL OF PATHOLOGY | 1997年 / 182卷 / 03期
关键词：
tumour infiltrating lymphocytes (TILs); colorectal cancer; prognosis;
D O I：
10.1002/(SICI)1096-9896(199707)182:3<318::AID-PATH862>3.0.CO;2-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Clinical follow-up data of 276 colorectal adenocarcinoma patients treated in Kuopio University Hospital between 1976 and 1986 and followed up for a mean of 14 years were analysed. The clinical findings were correlated with tumour-infiltrating lymphocytes (TILs) and with histological and quantitative factors including nuclear parameters and volume-corrected mitotic index. In univariate survival analysis, TNM classification, Dukes' stage, histological grade, and TILs were significant predictors of survival. TNM classification, Dukes' stage, and TILs also predicted recurrence-free survival. In multivariate analysis, TILs were an independent prognostic factor of survival in all cases, as well as in patients with T1-4N0-3M0 and T1-4N1-3M1. TILs also independently predicted recurrence-free survival. TILs can pro,ide important prognostic information in colorectal cancer to be used in evaluating for adjuvant therapy in different tumour stages. (C) 1997 by John Whey & Sons, Ltd.
引用
收藏
页码：318 / 324
页数：7
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