Individualized radiotherapy (iRT) concepts for locally advanced pancreatic cancer (LAPC): indications and prognostic factors

被引：3

作者：

Combs, Stephanie E. ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Radiat Oncol, D-81675 Munich, Bavaria, Germany

[2] Helmholtz Zentrum Munchen, Inst Innovat Radiotherapy iRT, D-85764 Neuherberg, Bavaria, Germany

来源：

LANGENBECKS ARCHIVES OF SURGERY | 2015年 / 400卷 / 07期

关键词：

Neoadjuvant chemoradiation; Locally advanced pancreatic cancer; Stereotactic body radiotherapy (SBRT); Radiotherapy; Personalized medicine; PHASE-II TRIAL; INTENSITY-MODULATED RADIOTHERAPY; GEMCITABINE-BASED CHEMORADIATION; EXTERNAL RADIATION TREATMENT; PACLITAXEL PLUS GEMCITABINE; ION-BEAM THERAPY; NAB-PACLITAXEL; NEOADJUVANT CHEMORADIATION; STEREOTACTIC RADIOTHERAPY; PROTON RADIOTHERAPY;

D O I：

10.1007/s00423-015-1309-8

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Novel techniques in radiation oncology have significantly improved the therapeutic window in locally advanced pancreatic cancer LAPC. In about one third of the patients, chemoradiation can lead to secondary resectability, contributing to an increase in outcome. Dose-escalation approaches using stereotactic body radiotherapy (SBRT) or advanced treatments such as intensity-modulated radiotherapy (IMRT) can exploit the biological benefits of hypofractionation, or use "dose painting" approaches to target defined subvolumes. Prognostic subgroups of patients have been identified, based on molecular markers such as CA 19-9, nutritional factors, diabetes or immunological properties of tumor and normal tissue. The aim of the present manuscript is to summarize data on downsizing for locally advanced pancreatic cancer (LAPC) and to elucidate the role of individualized radiotherapy (iRT). Future concepts focus on iRT based on prognostic factors leading to a true personalized treatment.

引用

页码：749 / 756

页数：8

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