Synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity via palladium-catalyzed heteroannulation of chiral arylpropargylic alcohols

被引：108

作者：

Botta, M ^{[1
]}

Summa, V ^{[1
]}

Corelli, F ^{[1
]}

DiPietro, G ^{[1
]}

Lombardi, P ^{[1
]}

机构：

[1] MENARINI RIC SUD SPA,I-00040 POMEZIA,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 05期

关键词：

D O I：

10.1016/0957-4166(96)00138-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-Iodophenol and 2-iodo-N-mesylaniline have been reacted with alpha-arylpropargylic alcohols of high enantiomeric purity under transition-metal catalysis leading to aryl 2-benzofuranyl and aryl 2-indolyl carbinols in good yield and high enantiomeric excess, thus constituting the first enantiospecific synthesis of these important classes of compounds. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1263 / 1266

页数：4

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