Nanotherapeutics engineered to cross the blood-brain barrier for advanced drug delivery to the central nervous system

被引：59

作者：

Kim, Jinhwan ^{[1
]}

Ahn, Song Ih ^{[1
]}

Kim, YongTae ^{[1
]}

机构：

[1] Georgia Inst Technol, Inst Elect & Nanotechnol, Parker H Petit Inst Bioengn & Biosci, George W Woodruff Sch Mech Engn,Wallace H Coulter, Atlanta, GA 30332 USA

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2019年 / 73卷

基金：

美国国家卫生研究院;

关键词：

Blood-brain barrier; Engineered nanoparticles; Nanomedicine; Drug delivery; Brain disease; SOLID LIPID NANOPARTICLES; TARGETED THERAPY; GLIOMA THERAPY; PENETRATING PEPTIDE; ALZHEIMERS-DISEASE; NANOMEDICINE; LIPOSOMES; TUMOR; GENE; TRANSFERRIN;

D O I：

10.1016/j.jiec.2019.01.021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug delivery to the brain remains challenging mainly due to the blood-brain barrier (BBB) that regulates the entrance of substances to the brain. Advances in nanotechnology have enabled the engineering of nanomedicines for biomedical applications including enhanced drug delivery into the brain. In this review, we describe strategies of nanomedicines engineered to traverse the BBB and deliver therapeutic molecules to target brain sites. We highlight the representative applications with materials including polymers, lipids, and inorganic elements for brain drug delivery. We finalize this review with the current challenges and future perspective of nanotherapeutics for advanced drug delivery to the brain. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：8 / 18

页数：11

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