Optimizing Unrelated Donor Cord Blood Transplantation

被引：33

作者：

Barker, Juliet N. ^{[1
]}

Rocha, Vanderson ^{[2
]}

Scaradavou, Andromachi ^{[3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[2] Hosp St Louis, Paris, France

[3] New York Blood Ctr, Natl Cord Blood Program, New York, NY 10021 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2009年 / 15卷 / 01期

关键词：

Hematologic malignancy; Allogeneic transplantation; Alternative donors; Cord blood; STEM-CELL TRANSPLANTATION; BONE-MARROW; IMMUNE RECONSTITUTION; PLACENTAL-BLOOD; ADULTS; RECIPIENTS; ENGRAFTMENT; OUTCOMES; SURVIVAL; RELAPSE;

D O I：

10.1016/j.bbmt.2008.10.020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In contrast to the very high transplant-related mortality (TRM) associated with the early experience of cord blood (CB) transplantation (CBT), recent transplant series have been associated with comparable survival to that of human leucocyte antigen (HLA)-matched unrelated donor transplantation in children with similarly promising results in adults. Consequently, the use of CB as an alternative stem cell source and the global inventory of units in public banks are rapidly increasing although challenges remain. This review will address efforts to optimize CBT from 3 different perspectives: that of the transplant center, the CBT registry, and the CB bank.

引用

页码：154 / 161

页数：8

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