Anticoagulation Strategies in Atrial Fibrillation

被引：4
作者：
Menezes, Arthur R. [1 ]
Artham, Surya [1 ]
Lavie, Carl J. [1 ,2 ]
Khatib, Sammy [1 ]
机构：
[1] Univ Queensland, Sch Med, Ochsner Clin Sch, Dept Cardiovasc Dis,John Ochsner Heart & Vasc Ins, New Orleans, LA USA
[2] Pennington Biomed Res Ctr, Dept Prevent Med, Baton Rouge, LA USA
来源：
REVIEWS IN CARDIOVASCULAR MEDICINE | 2012年 / 13卷 / 01期
关键词：
Atrial fibrillation; Stroke; Antithrombotic therapy; Warfarin; SHORT-TERM ANTICOAGULATION; DUAL-ANTIPLATELET THERAPY; STROKE PREVENTION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; ELECTRICAL CARDIOVERSION; ANTITHROMBOTIC THERAPY; RISK STRATIFICATION; PREDICTING STROKE; FACTOR XA; THROMBOEMBOLIC EVENTS;
D O I：
10.3909/ricm0616
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atrial fibrillation (AF) is a major risk factor for stroke and systemic embolization, particularly in the elderly. Approximately 2.3 million adults in the United States have AF, and it is projected that this number will increase to approximately 5.6 million individuals by the year 2050, with over 50% aged 80 years or older. Vitamin K antagonists are currently the most widely accepted means of stroke prevention in patients with AF; unfortunately, this method of treatment is not a feasible option for many patients for numerous reasons. This article examines and compares the various newer therapeutic agents that have either been approved by the US Food and Drug Administration or are still in various stages of clinical testing, and provides an overview of established antithrombotic therapies. We also discuss the role of anticoagulation in the setting of cardioversion in patients with AF. (C) 2012 MedReviews(R), LLC
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收藏
页码：E1 / E13
页数：13
相关论文
共 82 条
[51]   ACCURACY OF TRANSESOPHAGEAL ECHOCARDIOGRAPHY FOR IDENTIFYING LEFT ATRIAL THROMBI - A PROSPECTIVE, INTRAOPERATIVE STUDY [J].
MANNING, WJ ;
WEINTRAUB, RM ;
WAKSMONSKI, CA ;
HAERING, JM ;
ROONEY, PS ;
MASLOW, AD ;
JOHNSON, RG ;
DOUGLAS, PS .
ANNALS OF INTERNAL MEDICINE, 1995, 123 (11) :817-+
[52]   STROKE PREVENTION IN ATRIAL-FIBRILLATION STUDY - FINAL RESULTS [J].
MCBRIDE, R .
CIRCULATION, 1991, 84 (02) :527-539
[53]   LIMITATIONS OF TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN THE RISK ASSESSMENT OF PATIENTS BEFORE NONANTICOAGULATED CARDIOVERSION FROM ATRIAL-FIBRILLATION AND FLUTTER - AN ANALYSIS OF POOLED TRIALS [J].
MOREYRA, E ;
FINKELHOR, RS ;
CEBUL, RD .
AMERICAN HEART JOURNAL, 1995, 129 (01) :71-75
[54]  
Mousa SA, 2010, METHODS MOL BIOL, V663, P181, DOI 10.1007/978-1-60761-803-4_6
[55]   Absence of circulating microemboli in patients with atrial fibrillation undergoing electric cardioversion [J].
Nabavi, DG ;
Allroggen, A ;
Reinecke, H ;
Kemény, V ;
Droste, DW ;
Breithardt, G ;
Ringelstein, EB .
CEREBROVASCULAR DISEASES, 2001, 11 (02) :95-99
[56]   Dabigatran Versus Warfarin in Patients With Atrial Fibrillation An Analysis of Patients Undergoing Cardioversion [J].
Nagarakanti, Rangadham ;
Ezekowitz, Michael D. ;
Oldgren, Jonas ;
Yang, Sean ;
Chernick, Michael ;
Aikens, Timothy H. ;
Flaker, Greg ;
Brugada, Josep ;
Kamensky, Gabriel ;
Parekh, Amit ;
Reilly, Paul A. ;
Yusuf, Salim ;
Connolly, Stuart J. .
CIRCULATION, 2011, 123 (02) :131-136
[57]   Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study [J].
Olesen, Jonas Bjerring ;
Lip, Gregory Y. H. ;
Hansen, Morten Lock ;
Hansen, Peter Riis ;
Tolstrup, Janne Schurmann ;
Lindhardsen, Jesper ;
Selmer, Christian ;
Ahlehoff, Ole ;
Olsen, Anne-Marie Schjerning ;
Gislason, Gunnar Hilmar ;
Torp-Pedersen, Christian .
BMJ-BRITISH MEDICAL JOURNAL, 2011, 342 :320
[58]   High intensity anticoagulation for cardioversion of atrial arrhythmias? The shocking truth [J].
Olshansky, B .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (05) :934-936
[59]   Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors [J].
Olson, Steven T. ;
Richard, Benjamin ;
Izaguirre, Gonzalo ;
Schedin-Weiss, Sophia ;
Gettins, Peter G. W. .
BIOCHIMIE, 2010, 92 (11) :1587-1596
[60]   The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor [J].
Perzborn, Elisabeth ;
Roehrig, Susanne ;
Straub, Alexander ;
Kubitza, Dagmar ;
Misselwitz, Frank .
NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (01) :61-+
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