Stiff Person Syndrome

被引：40

作者：

Ciccotto, Giuseppe ^{[1
]}

Blaya, Maike ^{[1
]}

Kelley, Roger E. ^{[1
]}

机构：

[1] Tulane Univ, Sch Med, Dept Neurol, New Orleans, LA 70112 USA

来源：

NEUROLOGIC CLINICS | 2013年 / 31卷 / 01期

关键词：

Stiff person syndrome; Axial spasm; Anti-GAD antibodies; Autoimmune neuromuscular disorder; GLUTAMIC-ACID DECARBOXYLASE; PROGRESSIVE ENCEPHALOMYELITIS; LIMB SYNDROME; RIGIDITY; AUTOANTIBODIES; AUTOIMMUNITY; IMPROVEMENT; ANTIBODIES; PATIENT; REFLEX;

D O I：

10.1016/j.ncl.2012.09.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recognizing stiff person syndrome is clinically important. It is uncommon, characterized by body stiffness associated with painful muscle spasms, and varies in location and severity. It is subdivided into stiff trunk versus stiff limb presentation, and as a progressive encephalomyelitis. Stiff person-type syndrome also reflects a paraneoplastic picture. Most patients demonstrate exaggerated lumbar lordosis. Roughly 60% of patients have antiglutamic acid decarboxylase antibodies in the blood and the cerebrospinal fluid. The differential diagnosis includes many severe conditions. There are reports of response to muscle relaxants, immunosuppressants, intravenous gamma globulin, plasma exchange, a number of anticonvulsants, and botulinum toxin.

引用

页码：319 / +

页数：11

共 52 条

[1] Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: Protean additions to the autoimmune central neuropathies [J].

Ali, Fatima ;

Rowley, Merrill ;

Jayakrishnan, Bindu ;

Teuber, Suzanne ;

Gershwin, M. Eric ;

Mackay, Ian R. .

JOURNAL OF AUTOIMMUNITY, 2011, 37 (02) :79-87

[2] A neuropsychological assessment of phobias in patients with stiff person syndrome [J].

Ameli, R ;

Snow, J ;

Rakocevic, G ;

Dalakas, MC .

NEUROLOGY, 2005, 64 (11) :1961-1963

[3] A WOMAN WITH THE STIFF-MAN SYNDROME [J].

ASHER, R .

BRITISH MEDICAL JOURNAL, 1958, 1 (FEB1) :265-266

[4] Review of 23 patients affected by the stiff man syndrome: Clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity [J].

Barker, RA ;

Revesz, T ;

Thom, M ;

Marsden, CD ;

Brown, P .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 65 (05) :633-640

[5] Kinetic differences between the isoforms of glutamate decarboxylase: implications for the regulation of GABA synthesis [J].

Battaglioli, G ;

Liu, HC ;

Martin, DL .

JOURNAL OF NEUROCHEMISTRY, 2003, 86 (04) :879-887

[6] Head retraction reflex in stiff-man syndrome and related disorders [J].

Berger, C ;

Meinck, HM .

MOVEMENT DISORDERS, 2003, 18 (08) :906-911

[7] Stiff-person syndrome in a female patient with type 1 diabetes, dermatitis herpetiformis, celiac disease, microcytic anemia and copper deficiency Just a coincidence or an additional shared pathophysiological mechanism? [J].

Bilic, Ervina ;

Bilic, Ernest ;

Sepec, Branimir Ivan ;

Vranjes, Davorka ;

Zagar, Marija ;

Butorac, Visnja ;

Cerimagic, Denis .

CLINICAL NEUROLOGY AND NEUROSURGERY, 2009, 111 (07) :644-645

[8] THE STIFF MAN SYNDROME IN A BOY [J].

BOWLER, D .

ARCHIVES OF DISEASE IN CHILDHOOD, 1960, 35 (181) :289-292

[9] The serotonin syndrome [J].

Boyer, EW ;

Shannon, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (11) :1112-1120

[10] The stiff leg syndrome [J].

Brown, P ;

Rothwell, JC ;

Marsden, CD .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (01) :31-37

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