Layer-specific anatomical, physiological and functional MRI of the retina

被引:48
|
作者
Duong, Timothy Q. [1 ,2 ,5 ]
Pardue, Machelle T. [3 ,5 ]
Thule, Peter M. [4 ,5 ]
Olson, Darin E. [4 ,5 ]
Cheng, Haiying [2 ]
Nair, Govind [2 ]
Li, Yingxia [2 ]
Kim, Moon [5 ]
Zhang, Xiaodong [2 ]
Shen, Qiang [2 ]
机构
[1] Emory Univ, Yerkes Imaging Ctr, Div Neurosci, Yerkes Res Ctr,Dept Neurol, Atlanta, GA 30329 USA
[2] Emory Univ, Dept Radiol, Yerkes Imaging Ctr, Atlanta, GA 30329 USA
[3] Emory Univ, Dept Ophthalmol, Atlanta, GA 30322 USA
[4] Emory Univ, Dept Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA
[5] Atlanta Vet Affairs Med Ctr, Decatur, GA USA
关键词
choroid; retinal blood flow; BOLD; functional MRI; diffusion-weighted MRI; high resolution imaging; retinal diseases; manganese-enhanced MRI (MEMRI);
D O I
10.1002/nbm.1311
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Most retinal imaging has been performed using optical techniques. This paper reviews alternative retinal imaging methods based on MRI performed with spatial resolution sufficient to resolve multiple well-defined retinal layers. The development of these MRI technologies to study retinal anatomy, physiology (blood flow, blood volume, and oxygenation) and function, and their applications to the study of normal retinas, retinal degeneration and diabetic retinopathy in animal models are discussed. Although the spatiotemporal resolution of MRI is poorer than that of optical imaging techniques, it is unhampered by media opacity and can thus image all retinal and pararetinal structures, and has the potential to provide multiple unique clinically relevant data in a single setting and could thus complement existing retinal imaging techniques. In turn, the highly structured retina with well-defined layers is an excellent model for advancing emerging high-resolution anatomical, physiological and functional MRI technologies. Copyright (C) 2008 John Wiley & Sons. Ltd.
引用
收藏
页码:978 / 996
页数:19
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