Insights into the genetics of gastroesophageal reflux disease (GERD) and GERD-related disorders

被引：27
作者：
Boehmer, A. C. [1 ,2 ]
Schumacher, J. [1 ]
机构：
[1] Univ Bonn, Inst Human Genet, Bonn, Germany
[2] Univ Bonn, Dept Genom, Life & Brain Res Ctr, Bonn, Germany
来源：
NEUROGASTROENTEROLOGY AND MOTILITY | 2017年 / 29卷 / 02期
关键词：
barrett's esophagus; esophageal adenocarcinoma; gastroesophageal reflux disease; genome-wide association studies; shared genetic etiology; BARRETTS-ESOPHAGUS; HELICOBACTER-PYLORI; CYSTIC-FIBROSIS; HIATAL-HERNIA; CANCER-RISK; ADENOCARCINOMA; OBESITY; ACID; PATHOGENESIS; ASSOCIATION;
D O I：
10.1111/nmo.13017
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Gastroesophageal reflux disease (GERD) is associated with obesity and hiatal hernia, and often precedes the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). Epidemiological studies show that the global prevalence of GERD is increasing. GERD is a multifactorial disease with a complex genetic architecture. Genome-wide association studies (GWAS) have provided initial insights into the genetic background of GERD. The present review summarizes current knowledge of the genetics of GERD and a possible genetic overlap between GERD and BE and EA. The review discusses genes and cellular pathways that have been implicated through GWAS, and provides an outlook on how future molecular research will enhance understanding of GERD pathophysiology.
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