FRAIL scale: Predictive validity and diagnostic test accuracy

被引：50

作者：

Thompson, Mark Q. ^{[1
,2
]}

Theou, Olga ^{[1
,3
]}

Tucker, Graeme R. ^{[1
]}

Adams, Robert J. ^{[4
,5
]}

Visvanathan, Renuka ^{[1
,2
,6
]}

机构：

[1] Univ Adelaide, Natl Hlth & Med Res Council NHMRC, Ctr Res Excellence Frailty & Hlth Ageing, Adelaide, SA, Australia

[2] Univ Adelaide, Fac Hlth & Med Sci, Adelaide Geriatr Training & Res Aged Care G TRAC, Adelaide Med Sch, Adelaide, SA, Australia

[3] Dalhousie Univ, Dept Med, Halifax, NS, Canada

[4] Flinders Univ South Australia, Coll Med & Publ Hlth, Adelaide Inst Sleep Hlth, Adelaide, SA, Australia

[5] Southern Adelaide Local Hlth Network, Resp & Sleep Serv, Adelaide, SA, Australia

[6] Queen Elizabeth Hosp, Aged & Extended Care Serv, Cent Adelaide Local Hlth Network, Adelaide, SA, Australia

来源：

AUSTRALASIAN JOURNAL ON AGEING | 2020年 / 39卷 / 04期

关键词：

Australia; frailty; mortality; screening; DWELLING OLDER-PEOPLE; CLINICAL-PRACTICE; HEALTH; CARE; INSTRUMENTS; COHORT; RESPONSIVENESS; PHENOTYPE; MORTALITY; OUTCOMES;

D O I：

10.1111/ajag.12829

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60,P < .001). DTA findings were acceptable for specificity (86.8%) and Youden index (0.50), but not sensitivity (63.6%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of >= 2 characteristics was used rather than >= 3 in the primary DTA analysis. Conclusion The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.

引用

页码：E529 / E536

页数：8

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