Novel water-soluble 99mTc(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging

被引：33

作者：

Spagnul, Cinzia ^{[1
]}

Alberto, Roger ^{[2
]}

Gasser, Gilles ^{[2
]}

Ferrari, Stefano ^{[4
]}

Pierroz, Vanessa ^{[2
,4
]}

Bergamo, Alberta ^{[3
]}

Gianferrara, Teresa ^{[1
]}

Alessio, Enzo ^{[1
]}

机构：

[1] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

[2] Univ Zurich, Inst Inorgan Chem, CH-8057 Zurich, Switzerland

[3] Callerio Fdn Onlus, I-34127 Trieste, Italy

[4] Univ Zurich, Inst Mol Canc Res, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2013年 / 122卷

基金：

瑞士国家科学基金会;

关键词：

Porphyrin conjugates; Technetium; 99m; Rhenium; Radio-diagnostics; Molecular imaging; Multimodal imaging; PHOTODYNAMIC THERAPY; PORPHYRIN; COMPLEXES; TECHNETIUM; RHENIUM; CO2; METALLOPORPHYRINS; LIPOPROTEINS; DERIVATIVES; CHEMISTRY;

D O I：

10.1016/j.jinorgbio.2012.12.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and characterization of two novel water soluble porphyrins with three meso pyridyl rings and one peripheral chelator - either a diethylenetriamine unit (4) or a bipyridyl fragment (8) - for binding to the {Tc-99m(CO)(3)}(+) moiety is reported. In 8, despite the presence of a flexible and hydrophilic PEG-like linker that connects the bpy unit to the macrocycle, good water solubility was only obtained by methylation of the pyridyl N atoms that provided three extra positive charges. Furthermore, the water-soluble conjugates of 4 and 8 with either one fac-{Re(CO)(3)}(+) (9 and 10, respectively) or one fac-{Tc-99m(CO)(3)}(+) fragment (9a and 10a, respectively) are described. 0 2013 Published by Elsevier Inc.

引用

页码：57 / 65

页数：9

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