Use of aerosol route to fabricate positively charged Au/Fe3O4 Janus nanoparticles as multifunctional nanoplatforms

被引：11

作者：

Byeon, Jeong Hoon ^{[1
]}

Park, Jae Hong ^{[2
]}

机构：

[1] Yeungnam Univ, Sch Mech Engn, Gyongsan 38541, South Korea

[2] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

新加坡国家研究基金会;

关键词：

AU-FE3O4 DUMBBELL NANOPARTICLES; OPTICAL-PROPERTIES; GENERATION; MRI;

D O I：

10.1038/srep35104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gold (Au)-decorated iron oxide (Fe3O4), Au/Fe3O4, Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe3O4 domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities were tested in computed tomography (CT) and magnetic resonance (MR) imaging, gene-delivery and photothermal therapy. No additional polymeric coatings of the Janus particles also had a unique ability to suppress inflammatory responses in macrophages challenged with lipopolysaccharide, which may be due to the absence of amine groups.

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页数：7

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