The immunologic etiology of psychiatric manifestations in systemic lupus erythematosus: A narrative review on the role of the blood brain barrier, antibodies, cytokines and chemokines

被引:36
作者
Deijns, Sander J. [1 ,2 ]
Broen, Jasper C. A. [3 ,4 ]
Kruyt, Nyika D. [5 ]
Schubart, Chris D. [6 ]
Andreoli, Laura [7 ,8 ]
Tincani, Angela [7 ,8 ,9 ]
Limper, Maarten [10 ]
机构
[1] Univ Med Ctr Utrecht, NL-3584 CX Utrecht, Netherlands
[2] Univ Utrecht, NL-3584 CX Utrecht, Netherlands
[3] Maxima Med Ctr, Reg Rheumatol Ctr, NL-5631 BM Eindhoven, Netherlands
[4] Maxima Med Ctr, Reg Rheumatol Ctr, NL-5504 DB Veldhoven, Netherlands
[5] Leiden Univ, Med Ctr, Dept Neurol, NL-2333 ZA Leiden, Netherlands
[6] Tergooi Ziekenhuis, Dept Psychiat, NL-1261 AN Hilversum, Netherlands
[7] ASST Spedali Civili Brescia, Rheumatol & Clin Immunol Unit, I-25123 Brescia, BS, Italy
[8] Univ Brescia, Dept Clin & Expt Sci, I-25123 Brescia, BS, Italy
[9] IM Sechenov First Moscow State Med Univ, Moscow, Russia
[10] Univ Utrecht, Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, NL-3584 CX Utrecht, Netherlands
关键词
Neuropsychiatric systemic lupus erythematosus; Psychiatric; Blood-brain barrier; Antibody; Cytokine; Chemokine; RIBOSOMAL-P-PROTEIN; GLUTAMATE-RECEPTOR ANTIBODIES; SERUM LYMPHOCYTOTOXIC ANTIBODIES; SOUTHERN CHINESE PATIENTS; NECROSIS-FACTOR-ALPHA; CEREBROSPINAL-FLUID; NEUROPSYCHIATRIC MANIFESTATIONS; ANTIPHOSPHOLIPID ANTIBODIES; ANTICARDIOLIPIN ANTIBODIES; ANTINEURONAL ANTIBODIES;
D O I
10.1016/j.autrev.2020.102592
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction: The aim of this narrative review is to provide an overview of the literature on the possible immunologic pathophysiology of psychiatric manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE). Methods: A systematic search on PubMed was conducted. English studies with full text availability that investigated the correlation between blood-brain barrier (BBB) dysfunction, intrathecal synthesis of antibodies, antibodies, cytokines, chemokines, metalloproteinases, complement and psychiatric NPSLE manifestations in adults were included. Results: Both transient BBB-dysfunction with consequent access of antibodies to the cerebrospinal fluid (CSF) and intrathecal synthesis of antibodies could occur in psychiatric NPSLE. Anti-phospholipid antibodies, anti-NMDA antibodies and anti-ribosomal protein p antibodies seem to mediate concentration dependent neuronal dysfunction. Interferon-a may induce microglial engulfment of neurons, direct neuronal damage and production of cytokines and chemokines in psychiatric NPSLE. Several cytokines, chemokines and matrix metalloproteinase-9 may contribute to the pathophysiology of psychiatric NPSLE by attracting and activating Th1-cells and B-cells. Discussion: This potential pathophysiology may help understand NPSLE and may have implications for the diagnostic management and therapy of psychiatric NPSLE. However, the presented pathophysiological model is based on correlations between potential immunologic etiologies and psychiatric NPSLE that remain questionable. More research on this topic is necessary to further elucidate the pathophysiology of NPSLE.
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页数:15
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共 217 条
[1]   Association of anti-ribosomal P protein antibodies with neuropsychiatric and other manifestations of systemic lupus erythematosus [J].
Abdel-Nasser, Ahmed M. ;
Ghaleb, Rasha M. ;
Mahmoud, Jehan A. ;
Khairy, Wafaa ;
Mahmoud, Refaat M. .
CLINICAL RHEUMATOLOGY, 2008, 27 (11) :1377-1385
[2]   Neuropsychiatric manifestations in a consecutive cohort of systemic lupus erythematosus; a single center study [J].
Abdul-Sattar, Amal Bakry ;
Goda, Tarek ;
Negm, Mohamed G. .
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2013, 16 (06) :715-723
[3]   Neuropsychiatric lupus syndromes -: Relationship with antiphospholipid antibodies [J].
Afeltra, A ;
Garzia, P ;
Mitterhofer, AP ;
Vadacca, M ;
Galluzzo, S ;
Del Porto, F ;
Finamore, L ;
Pascucci, S ;
Gasparini, M ;
Laganà, B ;
Caccavo, D ;
Ferri, GM ;
Amoroso, A ;
Francia, A .
NEUROLOGY, 2003, 61 (01) :108-110
[4]   Increased serum matrix metalloproteinase 9 levels in systemic lupus erythematosus patients with neuropsychiatric manifestations and brain magnetic resonance imaging abnormalities [J].
Ainiala, H ;
Hietaharju, A ;
Dastidar, P ;
Loukkola, J ;
Lehtimäki, T ;
Peltola, J ;
Korpela, M ;
Heinonen, T ;
Nikkari, ST .
ARTHRITIS AND RHEUMATISM, 2004, 50 (03) :858-865
[5]   INTERLEUKIN-1 AND INTERLEUKIN-6 ACTIVITIES ARE INCREASED IN THE CEREBROSPINAL-FLUID OF PATIENTS WITH CNS LUPUS-ERYTHEMATOSUS AND CORRELATE WITH LOCAL LATE T-CELL ACTIVATION MARKERS [J].
ALCOCERVARELA, J ;
ALEMANHOEY, D ;
ALARCONSEGOVIA, D .
LUPUS, 1992, 1 (02) :111-117
[6]  
Almeida D, 2002, An Med Interna, V19, P73
[7]   Central nervous system (CNS) involvement in SLE - The diagnostic role of antibodies to neuronal antigens [J].
Alosachie, IJ ;
Terryberry, JW ;
Mevorach, D ;
Chapman, Y ;
Lorber, M ;
Torre, D ;
Youinou, P ;
Peter, JB ;
Shoenfeld, Y .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 1998, 16 (03) :275-284
[8]   Acute psychosis in systemic lupus erythematosus [J].
Appenzeller, Simone ;
Cendes, Fernando ;
Lavras Costallat, Lilian Tereza .
RHEUMATOLOGY INTERNATIONAL, 2008, 28 (03) :237-243
[9]   Cognitive Impairment and Employment Status in Systemic Lupus Erythematosus: A Prospective Longitudinal Study [J].
Appenzeller, Simone ;
Cendes, Fernando ;
Costallat, Lilian T. L. .
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2009, 61 (05) :680-687
[10]   Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus [J].
Aranow, Cynthia ;
Diamond, Betty ;
Mackay, Meggan .
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2010, 36 (01) :187-+