Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands

被引：43

作者：

Harpstrite, Scott E. ^{[1
]}

Collins, Silvia D. ^{[1
]}

Oksman, Ana ^{[2
,3
]}

Goldberg, Daniel E. ^{[2
,3
]}

Sharma, Vijay ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Howard Hughes Med Inst, Sch Med, St Louis, MO 63110 USA

[3] Washington Univ, Dept Med & Mol Microbiol, Sch Med, St Louis, MO 63110 USA

来源：

MEDICINAL CHEMISTRY | 2008年 / 4卷 / 04期

关键词：

naphthalene-amine; Schiff-base phenol; antimalarials; chloroquine-resistance; P; falciparum;

D O I：

10.2174/157340608784872280

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 mu M against CQ-resistant Dd2 strains.

引用

页码：392 / 395

页数：4

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