Aspirin and immune system

被引：82

作者：

Hussain, Muzammal ^{[1
]}

Javeed, Aqeel ^{[1
]}

Ashraf, Muhammad ^{[1
]}

Zhao, Yong ^{[2
]}

Mukhtar, Muhammad Mahmood ^{[3
]}

Rehman, Muti Ur ^{[4
]}

机构：

[1] Univ Vet & Anim Sci, Dept Pharmacol & Toxicol, Lahore 54600, Pakistan

[2] Chinese Acad Sci, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Inst Zool, Beijing 100101, Peoples R China

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Univ Vet & Anim Sci, Dept Pathol, Lahore 54600, Pakistan

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2012年 / 12卷 / 01期

关键词：

Aspirin; Autoimmunity; Immunosuppressant; NO-aspirin; Immune tolerance; Tolerogenic dendritic cells; PITUITARY-ADRENAL AXIS; NF-KAPPA-B; REGULATORY T-CELLS; TRIGGERED LIPOXIN A(4); BLOOD MONONUCLEAR-CELLS; GINKGO-BILOBA EXTRACT; NCX-4016; NO-ASPIRIN; LOW-DOSE ASPIRIN; NITRIC-OXIDE; DENDRITIC CELLS;

D O I：

10.1016/j.intimp.2011.11.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The time-tested gradual exploration of aspirin's diverse pharmacological properties has made it the most reliable therapeutic agent worldwide. In addition to its well-argued anti-inflammatory effects, many new and exciting data have emerged regarding the role of aspirin in cells of the immune system and certain immunopathological states. For instance, aspirin induces tolerogenic activity in dendritic cells and determines the fate of naive T cells to regulatory phenotypes, which suggests its immunoregulatory potential in relevance to immune tolerance. It also displays some intriguing traits to modulate the innate and adaptive immune responses. In this article, the immunomodulatory relation of aspirin to different immune cells, such as neutrophils, macrophages, dendritic cells (DCs), natural killer (NK) cells, and the T and B lymphocytes has been highlighted. Moreover, the clinical prospects of aspirin in terms of autoimmunity, allograft rejection and immune tolerance have also been outlined. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：10 / 20

页数：11

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