Interleukin-7, a new immunoadjuvant for the treatment of septic shock

被引：3

作者：

Monneret, Guillaume ^{[1
,2
]}

Villars-Mechin, Astrid ^{[1
]}

Demaret, Julie ^{[1
,2
]}

Foray, Anne-Perrine ^{[1
]}

Venet, Fabienne ^{[1
,2
]}

机构：

[1] Hop Edouard Herriot, Lab Immunol Cellulaire, Hosp Civils Lyon, F-69437 Lyon 03, France

[2] Univ Lyon 1, Hosp Civils Lyon, EAM Hemostase 4174, F-69365 Lyon, France

来源：

M S-MEDECINE SCIENCES | 2014年 / 30卷 / 02期

关键词：

DELAYED-HYPERSENSITIVITY; PROLONGED LYMPHOPENIA; IMMUNE DYSFUNCTIONS; SEVERE SEPSIS; T-CELLS; IL-7; IMMUNOSUPPRESSION; MODEL;

D O I：

10.1051/medsci/20143002013

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sepsis-induced immunosuppression is a new paradigm in sepsis pathophysiology. This up-to-date review integrates recent facts in the field. It focuses on immune dysfunctions described so far in septic patients (especially regarding T lymphocytes), on the mechanisms sustaining this immune failure, on the monitoring of the pro-/anti-inflammatory balance rapidly changing over time and on new promising therapeutic avenues emerging from those recent findings. Of them, the case of interleukin-7 is more specifically envisaged.

引用

页码：160 / 165

页数：6

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