Cell death decision by p53 via control of the mitochondrial membrane

被引：89
作者：
Dashzeveg, Nurmaa [1 ]
Yoshida, Kiyotsugu [1 ]
机构：
[1] Jikei Univ, Sch Med, Dept Biochem, Minato Ku, Tokyo 1058461, Japan
来源：
CANCER LETTERS | 2015年 / 367卷 / 02期
基金：
日本学术振兴会;
关键词：
p53; Mitochondria; Apoptosis; Necrosis; Necroptosis; TUMOR-SUPPRESSOR P53; DNA-BINDING DOMAIN; BCL-2; FAMILY; MULTIDRUG-RESISTANCE; TARGETING BCL2; IN-VITRO; BAX; APOPTOSIS; NECROSIS; PUMA;
D O I：
10.1016/j.canlet.2015.07.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The tumor suppressor p53 is mutated in more than half of human cancers. Recent evidence has revealed that p53 not only regulates apoptosis but also regulates necrotic/necroptotic cell death via the mitochondria. The regulation of apoptosis by p53 is tightly connected to the mitochondrial outer membrane permeabilization and the induction of and interaction with Bcl-2 family members. Interestingly, p53-mediated regulation of necrosis/necroptosis is correlated with mitochondrial permeabilization pore opening via interactions with CypD and Drp1. This review discusses the p53-regulating molecules that induce apoptosis or necrosis/necroptosis via the mitochondria. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：108 / 112
页数：5
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