Incorporation of 6-Thioguanine Nucleotides into DNA During Maintenance Therapy of Childhood Acute Lymphoblastic LeukemiaThe Influence of Thiopurine Methyltransferase Genotypes

被引：35

作者：

Ebbesen, Maria S. ^{[1
]}

Nersting, Jacob ^{[1
]}

Jacobsen, Jack H. ^{[1
]}

Frandsen, Thomas L. ^{[1
]}

Vettenranta, Kim ^{[2
]}

Abramsson, Jonas ^{[3
]}

Wesenberg, Finn ^{[4
]}

Schmiegelow, Kjeld ^{[1
,5
]}

机构：

[1] Rigshosp, Univ Hosp, Dept Pediat & Adolescent Med, DK-2100 Copenhagen, Denmark

[2] Univ Tampere, Div Hematol Oncol, Dept Pediat, FIN-33101 Tampere, Finland

[3] Univ Gothenburg, Dept Pediat, Inst Clin Sci, Sahlgrenska Acad, Gothenburg, Sweden

[4] Univ Oslo, Dept Pediat, Oslo Univ Hosp, Fac Med, Oslo, Norway

[5] Univ Copenhagen, Inst Gynecol Obstet & Pediat, Fac Med, Copenhagen, Denmark

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 2013年 / 53卷 / 06期

关键词：

acute lymphoblastic leukemia; thiopurines; DNA-TG; thiopurine methyltransferase; maintenance therapy; LIQUID-CHROMATOGRAPHY; RANDOMIZED-TRIAL; NOPHO ALL-92; PHARMACOGENETICS; TOXICITY; RISK; 6-MERCAPTOPURINE; MERCAPTOPURINE; THIOGUANINE; METABOLISM;

D O I：

10.1002/jcph.81

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：670 / 674

页数：5

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