Autophagy and neurodegenerative disorders

被引:78
作者
Kesidou, Evangelia [1 ]
Lagoudaki, Roza [1 ]
Touloumi, Olga [1 ]
Poulatsidou, Kyriaki-Nefeli [1 ]
Simeonidou, Constantina [2 ]
机构
[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Neurol 2, Lab Expt Neurol & Neuroimmunol, GR-54006 Thessaloniki, Macedonia, Greece
[2] Aristotle Univ Thessaloniki, Sch Med, Dept Expt Physiol, GR-54006 Thessaloniki, Macedonia, Greece
关键词
neural regeneration; reviews; oxidative stress; autophagy; autophagy-related genes; apoptosis; Parkinson's disease; amyotrophic lateral sclerosis; multiple sclerosis; acute and chronic neurodegeneration; neuroregeneration; AMYOTROPHIC-LATERAL-SCLEROSIS; CHAPERONE-MEDIATED AUTOPHAGY; TRAUMATIC BRAIN-INJURY; SPINAL-CORD-INJURY; CELL-DEATH; HUNTINGTONS-DISEASE; MULTIPLE-SCLEROSIS; ALPHA-SYNUCLEIN; NEURONAL DEATH; ALZHEIMER-DISEASE;
D O I
10.3969/j.issn.1673-5374.2013.24.007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders.
引用
收藏
页码:2275 / 2283
页数:9
相关论文
共 86 条
[11]   Oxidative stress and lysosomes: CNS-related consequences and implications for lysosomal enhancement strategies and induction of autophagy [J].
Butler, D ;
Bahr, BA .
ANTIOXIDANTS & REDOX SIGNALING, 2006, 8 (1-2) :185-196
[12]   Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury [J].
Carloni, Silvia ;
Buonocore, Giuseppe ;
Balduini, Walter .
NEUROBIOLOGY OF DISEASE, 2008, 32 (03) :329-339
[13]   Autophagy Is Activated in Injured Neurons and Inhibited by Methylprednisolone After Experimental Spinal Cord Injury [J].
Chen, Hsien-Chih ;
Fong, Tsorng-Harn ;
Lee, Ai-Wei ;
Chiu, Wen-Ta .
SPINE, 2012, 37 (06) :470-475
[14]   Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy [J].
Cuervo, AM ;
Stefanis, L ;
Fredenburg, R ;
Lansbury, PT ;
Sulzer, D .
SCIENCE, 2004, 305 (5688) :1292-1295
[15]   A receptor for the selective uptake and degradation of proteins by lysosomes [J].
Cuervo, AM ;
Dice, JF .
SCIENCE, 1996, 273 (5274) :501-503
[16]  
Dello Russo C, GLIA IN PRESS
[17]  
Dice J.F., 2000, LYSOSOMAL PATHWAYS P
[18]   PEPTIDE SEQUENCES THAT TARGET CYTOSOLIC PROTEINS FOR LYSOSOMAL PROTEOLYSIS [J].
DICE, JF .
TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (08) :305-309
[19]   Closed head injury induces upregulation of Beclin 1 at the cortical site of injury [J].
Diskin, T ;
Tal-Or, P ;
Erlich, S ;
Mizrachy, L ;
Alexandrovich, A ;
Shohami, E ;
Pinkas-Kramarski, R .
JOURNAL OF NEUROTRAUMA, 2005, 22 (07) :750-762
[20]   Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1 [J].
Djavaheri-Mergny, M. ;
Maiuri, M. C. ;
Kroemer, G. .
ONCOGENE, 2010, 29 (12) :1717-1719