Autophagy and neurodegenerative disorders

被引：78

作者：

Kesidou, Evangelia ^{[1
]}

Lagoudaki, Roza ^{[1
]}

Touloumi, Olga ^{[1
]}

Poulatsidou, Kyriaki-Nefeli ^{[1
]}

Simeonidou, Constantina ^{[2
]}

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Neurol 2, Lab Expt Neurol & Neuroimmunol, GR-54006 Thessaloniki, Macedonia, Greece

[2] Aristotle Univ Thessaloniki, Sch Med, Dept Expt Physiol, GR-54006 Thessaloniki, Macedonia, Greece

来源：

NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 24期

关键词：

neural regeneration; reviews; oxidative stress; autophagy; autophagy-related genes; apoptosis; Parkinson's disease; amyotrophic lateral sclerosis; multiple sclerosis; acute and chronic neurodegeneration; neuroregeneration; AMYOTROPHIC-LATERAL-SCLEROSIS; CHAPERONE-MEDIATED AUTOPHAGY; TRAUMATIC BRAIN-INJURY; SPINAL-CORD-INJURY; CELL-DEATH; HUNTINGTONS-DISEASE; MULTIPLE-SCLEROSIS; ALPHA-SYNUCLEIN; NEURONAL DEATH; ALZHEIMER-DISEASE;

D O I：

10.3969/j.issn.1673-5374.2013.24.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders.

引用

页码：2275 / 2283

页数：9

共 86 条

[1] Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].