Gastrointestinal Transit Time, Glucose Homeostasis and Metabolic Health: Modulation by Dietary Fibers

被引：196
作者：
Muller, Mattea [1 ]
Canfora, Emanuel E. [1 ]
Blaak, Ellen E. [1 ]
机构：
[1] Maastricht Univ, Med Ctr, Dept Human Biol, NUTRIM Sch Nutr & Translat Res Metab, Univ Singel 50,POB 616, NL-6200 MD Maastricht, Netherlands
来源：
NUTRIENTS | 2018年 / 10卷 / 03期
关键词：
dietary fiber; gastrointestinal transit; microbiota; obesity; type; 2; diabetes; SUSTAINED PECTIN INGESTION; SMALL-INTESTINAL TRANSIT; MIGRATING MOTOR COMPLEX; GUT MICROBIOTA; GUAR GUM; CEREAL-FIBER; WHOLE-GRAIN; DIABETES-MELLITUS; BOWEL FUNCTION; MICROCRYSTALLINE CELLULOSE;
D O I：
10.3390/nu10030275
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Gastrointestinal transit time may be an important determinant of glucose homeostasis and metabolic health through effects on nutrient absorption and microbial composition, among other mechanisms. Modulation of gastrointestinal transit may be one of the mechanisms underlying the beneficial health effects of dietary fibers. These effects include improved glucose homeostasis and a reduced risk of developing metabolic diseases such as obesity and type 2 diabetes mellitus. In this review, we first discuss the regulation of gastric emptying rate, small intestinal transit and colonic transit as well as their relation to glucose homeostasis and metabolic health. Subsequently, we briefly address the reported health effects of different dietary fibers and discuss to what extent the fiber-induced health benefits may be mediated through modulation of gastrointestinal transit.
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页数：18
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