Th1- and Th2-like subsets of innate lymphoid cells

被引：32

作者：

Bernink, Jochem ^{[1
]}

Mjosberg, Jenny ^{[2
]}

Spits, Hergen ^{[1
]}

机构：

[1] Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, NL-1105 BK Amsterdam, Netherlands

[2] Karolinska Inst, Karolinska Univ Hosp Huddinge, Ctr Infect Med, Dept Med, Stockholm, Sweden

来源：

IMMUNOLOGICAL REVIEWS | 2013年 / 252卷

关键词：

innate lymphoid cells; natural killer cells; Th1/Th2/Th17; cells; asthma; inflammatory bowel disease; group; 1; ILCs; 2; TRANSCRIPTION FACTOR GATA3; TISSUE-INDUCER CELLS; NATURAL HELPER-CELLS; ROR-GAMMA-T; INTESTINAL INFLAMMATION; EXPRESSION; IL-13; INSIGHTS; RECEPTOR; ALPHA;

D O I：

10.1111/imr.12034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILCs) constitute a family of effectors in innate immunity and regulators of tissue remodeling that have a cytokine and transcription factor expression pattern that parallels that of the T-helper (Th) cell family. Here, we discuss how ILCs can be categorized and summarize the current knowledge of Th1- and Th2-like ILCs with regard to the molecular mechanisms of development, effector functions, and their interplay with other cell types.

引用

页码：133 / 138

页数：6

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