Drusen and lipid-filled retinal pigment epithelium cells in a rhesus macula

被引：23

作者：

Anderson, M

Dawson, WW ^{[1
]}

Gonzalez-Martinez, J

Curcio, CA

机构：

[1] Univ Alabama Birmingham, Dept Ophthalmol, Birmingham, AL 35294 USA

[2] Univ Florida, Dept Ophthalmol, Gainesville, FL USA

[3] Univ Puerto Rico, Caribbean Primate Res Ctr, Sabana Seca, PR USA

来源：

VETERINARY OPHTHALMOLOGY | 2006年 / 9卷 / 03期

关键词：

aging; drusen; lipids; macular disease; pigment epithelium cells; primate; rhesus;

D O I：

10.1111/j.1463-5224.2006.00463.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A middle-aged rhesus monkey with detailed clinical history exhibited progression of a macular abnormality with a variety of clinical drusen and pigment changes typical of the Cayo Santiago phenotype. Numerous frozen sections of one sample of the macular retina/retinal pigment epithelium (RPE)/choroid showed a single classical druse but extensive single and clustered lipid-filled RPE cells. The monkey exhibited functional outer retinal decline and an insignificant number of 'window defects' as found among signs of relatively benign human macular aging. The clinical and histologically defined results agree if lipid-filled RPE cells are included among the clinically apparent signs of drusen.

引用

页码：201 / 207

页数：7

共 47 条

[1] Drusen in age-related macular degeneration: Pathogenesis, natural course, and laser photocoagulation-induced regression [J].