Reaction of 7-phenyl-7H-pyrazolo-[3,4-d][1,2,3]triazin-4-ol with thionyl chloride

被引：3

作者：

Khutova, B. M. ^{[1
]}

Klyuchko, S. V. ^{[1
]}

Gurenko, A. O. ^{[1
]}

Vasilenko, A. N. ^{[1
]}

Rusanov, E. B. ^{[2
]}

Brovarets, V. S. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02660 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 06期

关键词：

dimethyl formamide; pyrazole; pyrazolopyrimidine; pyrazolotriazine; thionyl chloride; ANTIMICROBIAL ACTIVITIES; DERIVATIVES; 5(4)-AMINOIMIDAZOLE-4(5)-CARBOXAMIDE; ANTITUMOR; PYRAZOLES; PURINES; ANALOGS; SERIES; AGENTS;

D O I：

10.1007/s10593-013-1327-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 7-phenyl-7H-pyrazolo[3,4-d][1,2,3]triazin-4-ol with thionyl chloride has been studied in the presence and absence of dimethyl formamide. It was found that heating the compound with thionyl chloride in the absence of dimethyl formamide gave 5-amino-1-phenyl-1H-pyrazole-4-carboxylic acid chloride and in its presence a mixture of 5-chloro-N-formyl-1-phenyl-1H-pyrazole-4-carboxamide, 5-chloro-1-phenyl-1H-pyrazole-4-carboxamide, and 4-chloro-6-(5-chloro-1-phenyl-1H-pyrazol-4-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine.

引用

页码：922 / 929

页数：8

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