MDM2, MDMX and p53 in oncogenesis and cancer therapy

被引：1000

作者：

Wade, Mark ^{[1
]}

Li, Yao-Cheng ^{[2
]}

Wahl, Geoffrey M. ^{[2
]}

机构：

[1] Fdn Ist ltaliano Tecnol IIT, Ctr Genom Sci IIT SEMM, I-20139 Milan, Italy

[2] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

DOUBLE MINUTE 2; UBIQUITIN LIGASE ACTIVITY; SMALL-MOLECULE INHIBITORS; ESTROGEN-RECEPTOR-ALPHA; STRUCTURE-BASED DESIGN; DNA-DAMAGE; CELL-DEATH; HEPATOCELLULAR-CARCINOMA; EMBRYONIC LETHALITY; ANDROGEN RECEPTOR;

D O I：

10.1038/nrc3430

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour suppressor. However, the MDM proteins modulate and respond to many other signalling networks in which they are embedded. Recent mechanistic studies and animal models have demonstrated how functional interactions in these networks are crucial for maintaining normal tissue homeostasis, and for determining responses to oncogenic and therapeutic challenges. This Review highlights the progress made and pitfalls encountered as the field continues to search for MDM-targeted antitumour agents.

引用

页码：83 / 96

页数：14

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