Asymmetric dimethylarginine is associated with carotid atherosclerosis in patients with essential hypertension

被引：3

作者：

Xia, Wei ^{[1
]}

Xu, Li ^{[1
]}

Xu, Wenliang ^{[1
]}

Wang, Xu ^{[1
]}

Yao, Yingjie ^{[1
]}

机构：

[1] Qingdao Municipal Hosp, Dept Cardiol, Shandong, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2015年 / 37卷 / 05期

关键词：

Asymmetric dimethylarginine; atherosclerosis; carotid plaque; essential hypertension; intima-media thickness; INTIMA-MEDIA THICKNESS; OXIDE SYNTHASE INHIBITOR; NITRIC-OXIDE; ADHESION MOLECULE-1; PLASMA-LEVELS; L-ARGININE; ADMA; ADHESIVENESS; DYSFUNCTION;

D O I：

10.3109/10641963.2014.987393

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study was to assess the relationship between asymmetric dimethylarginine (ADMA) and carotid atherosclerosis in patients with essential hypertension. A total of 182 individuals with never-treated essential hypertension and 182 age-matched healthy controls were studied. Plasma ADMA levels, mean intima-media thickness (IMT) and plaque score were significantly greater in hypertensive patients than normotensive controls. ADMA was positively correlated with mean IMT. On multiple logistic regression analysis, ADMA was a crucial independent predictor of carotid plaque formation (plaque score >= 1.1). Our results suggest that increased levels of ADMA are associated with the development of carotid atherosclerosis in hypertensive patients.

引用

页码：393 / 397

页数：5

共 24 条

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