Asymmetric dimethylarginine is associated with carotid atherosclerosis in patients with essential hypertension

被引：3
作者：
Xia, Wei [1 ]
Xu, Li [1 ]
Xu, Wenliang [1 ]
Wang, Xu [1 ]
Yao, Yingjie [1 ]
机构：
[1] Qingdao Municipal Hosp, Dept Cardiol, Shandong, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2015年 / 37卷 / 05期
关键词：
Asymmetric dimethylarginine; atherosclerosis; carotid plaque; essential hypertension; intima-media thickness; INTIMA-MEDIA THICKNESS; OXIDE SYNTHASE INHIBITOR; NITRIC-OXIDE; ADHESION MOLECULE-1; PLASMA-LEVELS; L-ARGININE; ADMA; ADHESIVENESS; DYSFUNCTION;
D O I：
10.3109/10641963.2014.987393
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study was to assess the relationship between asymmetric dimethylarginine (ADMA) and carotid atherosclerosis in patients with essential hypertension. A total of 182 individuals with never-treated essential hypertension and 182 age-matched healthy controls were studied. Plasma ADMA levels, mean intima-media thickness (IMT) and plaque score were significantly greater in hypertensive patients than normotensive controls. ADMA was positively correlated with mean IMT. On multiple logistic regression analysis, ADMA was a crucial independent predictor of carotid plaque formation (plaque score >= 1.1). Our results suggest that increased levels of ADMA are associated with the development of carotid atherosclerosis in hypertensive patients.
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收藏
页码：393 / 397
页数：5
相关论文
共 24 条
  • [1] Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase
    Achan, V
    Broadhead, M
    Malaki, M
    Whitley, G
    Leiper, J
    MacAllister, R
    Vallance, P
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (08) : 1455 - 1459
  • [2] Nitric oxide and arterial disease
    Barbato, JE
    Tzeng, E
    [J]. JOURNAL OF VASCULAR SURGERY, 2004, 40 (01) : 187 - 193
  • [3] An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes
    Böger, RH
    Bode-Böger, SM
    Tsao, PS
    Lin, PS
    Chan, JR
    Cooke, JP
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (07) : 2287 - 2295
  • [4] The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor
    Böger, RH
    [J]. CARDIOVASCULAR RESEARCH, 2003, 59 (04) : 824 - 833
  • [5] Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans
    Chan, JR
    Böger, RH
    Bode-Böger, SM
    Tangphao, O
    Tsao, PS
    Blaschke, TF
    Cooke, JP
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (04) : 1040 - 1046
  • [6] PREDICTION OF CREATININE CLEARANCE FROM SERUM CREATININE
    COCKCROFT, DW
    GAULT, MH
    [J]. NEPHRON, 1976, 16 (01) : 31 - 41
  • [7] Cooke JP, 1997, CIRCULATION, V96, P379
  • [8] Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age - The muscatine study
    Davis, PH
    Dawson, JD
    Riley, WA
    Lauer, RM
    [J]. CIRCULATION, 2001, 104 (23) : 2815 - 2819
  • [9] K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification - Foreword
    Eknoyan, G
    Levin, NW
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (02) : S14 - S266
  • [10] Plasma level of asymmetric dimethylarginine (ADMA) as a predictor of carotid intima-media thickness progression: Six-year prospective study using carotid ultrasonography
    Furuki, Kumiko
    Adachi, Hisashi
    Enomoto, Mika
    Otsuka, Maki
    Fukami, Ako
    Kumagae, Shun-ichi
    Matsuoka, Hidehiro
    Nanjo, Yasuki
    Kakuma, Tatsuyuki
    Imaizumi, Tsutomu
    [J]. HYPERTENSION RESEARCH, 2008, 31 (06) : 1185 - 1189
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