Cytotoxic isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata

被引：46
作者：
Fouad, M
Edrada, RA
Ebel, R
Wray, V
Müller, WEG
Lin, WH
Proksch, P
机构：
[1] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany
[2] Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany
[3] Johannes Gutenberg Univ Mainz, Inst Physiol Chem & Pathobiochem, D-55128 Mainz, Germany
[4] Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 02期
关键词：
D O I：
10.1021/np050346t
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Fourteen isomalabaricane triterpenes were isolated from the marine sponge Rhabdastrella globostellata. In addition to the known compounds globostellatic acids A (1) and D (4) and stelliferin riboside (13), 11 of the compounds were new natural products, which included globostelletin (3), eight new globostellatic acid congeners, F to M (2, 5-11), and two new stelliferin ribosides (12 and 14). The isolated compounds were tested against three different cancer cell lines, L5178Y (mouse lymphoma), HeLa (human cervix carcinoma), and PC-12 (rat pheochromocytoma). The isomalabaricane derivatives were found to be selectively active toward the Muse lymphoma cell line L5178Y. The structures were determined by 1D and 2D NMR data and by comparison with spectroscopic data of known related compounds.
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页码：211 / 218
页数：8
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