Impact of Mixed Aortic Valve Stenosis on VARC-2 Outcomes and Postprocedural Aortic Regurgitation in Patients Undergoing Transcatheter Aortic Valve Implantation: Results From the International Multicentric Study PRAGMATIC (Pooled Rotterdam-Milan-Toulouse in Collaboration)

被引:29
作者
Chieffo, Alaide [1 ]
Van Mieghem, Nicolas M. [2 ]
Tchetche, Didier [3 ]
Dumonteil, Nicolas [4 ]
Giustino, Gennaro [1 ]
Van der Boon, Robert M. A. [2 ]
Pierri, Adele [3 ]
Marcheix, Bertrand [4 ]
Misuraca, Leonardo [3 ]
Serruys, Patrick W. [2 ]
Millischer, Damien [3 ]
Carrie, Didier [4 ]
de Jaegere, Peter P. T. [2 ]
Colombo, Antonio [1 ]
机构
[1] Ist Sci San Raffaele, Dept CardioThorac & Vasc Dis, I-20132 Milan, Italy
[2] Erasmus MC, Thoraxctr, Dept Intervent Cardiol, Rotterdam, Netherlands
[3] Clin Pasteur, Dept Cardiol, Toulouse, France
[4] Hop Rangueil, Pole Cardiovasc & Metab, Toulouse, France
关键词
TAVI; mixed aortic stenosis; postprocedural aortic regurgitation; REPLACEMENT; DISEASE;
D O I
10.1002/ccd.25975
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectivesWe sought to evaluate the impact of mixed aortic stenosis (MAS) on postprocedural aortic regurgitation (PPAR) and clinical outcomes after transcatheter aortic valve implantation (TAVI). BackgroundThe impact of MAS of TAVI outcomes is unknown. Methods and ResultsData from a multicenter registry were retrospectively analysed. Outcomes were compared between patients with pure aortic stenosis (PAS; associated AR<1+/3+) and MAS (associated AR1+/3+). Study objectives were PPAR incidence and short- and long-term mortality. Overall, 1,062 patients were included: 419 (39.4%) with MAS and 643 (60.5%) with PAS. At 30 days, there were no differences in mortality, however, a higher incidence of major bleeding (22.7% vs. 16.8%; P = 0.016), PPAR1+/3+ (42.6% vs. 26.5%; P < 0.001) and lower device success (89.3% vs. 93.3%; P = 0.019) was observed in patients with MAS. Of note, MAS was an independent predictor of PPAR1+/3+ at multivariable analysis (OR: 2.882; CI: 1.851-4.488; P < 0.001). At 2 years of follow-up, no survival differences were present between MAS and PAS groups. Similarly, following stratification for PPAR1+/3+, MAS had no protective effect on survival as compared with PAS. ConclusionsMAS was associated with lower device success and higher PPAR incidence. However, despite these findings, it had no influence on long-term postoperative outcomes. (c) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:875 / 885
页数:11
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