Ordered mesoporous silica material SBA-15: loading of new calcium channel blocker - lacidipine

被引：13

作者：

Kiwilsza, A. ^{[2
]}

Mielcarek, J. ^{[1
]}

Pajzderska, A.

Wasicki, J.

机构：

[1] Poznan Univ Med Sci, Dept Inorgan & Analyt Chem, PL-60780 Poznan, Poland

[2] Adam Mickiewicz Univ, Fac Phys, NanoBioMed Ctr, PL-61614 Poznan, Poland

来源：

JOURNAL OF MICROENCAPSULATION | 2013年 / 30卷 / 01期

关键词：

SBA-15; mesoporous silica; dihydropyridine derivatives; lacidipine; drug delivery system; CARRIERS; RELEASE; ITRACONAZOLE; NIFEDIPINE; ADSORPTION; GENERATION; DELIVERY;

D O I：

10.3109/02652048.2012.692401

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Mesoporous material SBA-15 of hexagonal structure was synthesised and its usefulness as a carrier for a poorly soluble drug - lacidipine (LA) - was tested. The source of silica was tetraethyl orthosilicate (TEOS) and the structure ordering agent was non-ionic surfactant Pluronic P123. SBA-15 with encapsulated LA was characterised by X-ray diffraction (XRD), infrared spectroscopy (FTIR), thermogravimetry (TG), differential scanning calorimetry (DSC) and transmission electron microscopy (TEM). Adsorption of the therapeutically active substance was performed in anhydrous environment (chloroform). The content of the therapeutic substance in SBA-15 estimated from TG measurements reached 9%. The properties of the compound obtained were compared with those of a physical mixture of the components.

引用

页码：21 / 27

页数：7

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