Development of intestinal microbiota in infants and its impact on health

被引:383
作者
Matamoros, Sebastien [1 ]
Gras-Leguen, Christele [2 ]
Le Vacon, Francoise [3 ]
Potel, Gilles [2 ]
de La Cochetiere, Marie-France [4 ]
机构
[1] Univ Laval, INAF, Quebec City, PQ G1V 0A6, Canada
[2] Univ Nantes, Therapeut Clin & Expt Infect UFR Med, Dept Malad Infect, F-44035 Nantes, France
[3] Biofortis SAS, Merieux NutriSci, F-44800 St Herblain, France
[4] Univ Nantes, INSERM, Dept Malad Infect, Therapeut Clin & Expt Infect UFR Med, F-44035 Nantes, France
关键词
microbiota; newborn; colonization; disease; personalized therapy; 16S RIBOSOMAL-RNA; WEIGHT PRETERM INFANTS; GUT MICROBIOTA; HUMAN-MILK; PROBIOTIC INTERVENTION; BACTERIAL-COLONIZATION; FECAL MICROBIOTA; DELIVERY MODE; DOUBLE-BLIND; BREAST-MILK;
D O I
10.1016/j.tim.2012.12.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Throughout the human lifetime, the intestinal microbiota performs vital functions, such as barrier function, metabolic reactions, trophic effects, and maturation of the host's innate and adaptive immune responses. Development of the intestinal microbiota in infants is characterized by rapid and large changes in microbial abundance, diversity, and composition. These changes are influenced by medical, cultural, and environmental factors such as mode of delivery, diet, familial environment, diseases, and therapies used. Thus, it is nearly impossible to define a universal standard for intestinal colonization and development of the intestinal microbiota. This review discusses recent data on the early colonization of the gut by microbial species, development of the intestinal microbiota, and its impact on health.
引用
收藏
页码:167 / 173
页数:7
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