Response Assessment in Neuro-Oncology Criteria and Clinical Endpoints

被引:26
作者
Huang, Raymond Y. [1 ]
Wen, Patrick Y. [2 ]
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Div Neuroradiol, 75 Francis St, Boston, MA 02115 USA
[2] Harvard Med, Brigham & Womens Hosp, Dana Farber Brigham & Womens Canc Ctr, Ctr Neurooncol,Dept Neurol,Div Neurooncol, Boston, MA 02215 USA
关键词
RANO; Response assessment; Endpoints; Gliomas; Brain metastases; APPARENT DIFFUSION-COEFFICIENT; MAGNETIC-RESONANCE-SPECTROSCOPY; PROTON MR SPECTROSCOPY; CEREBRAL BLOOD-VOLUME; ACRIN; 6677/RTOG; 0625; HIGH-GRADE GLIOMAS; PHASE-II TRIAL; BEVACIZUMAB PLUS IRINOTECAN; SINGLE-AGENT BEVACIZUMAB; TUMOR BRAIN METASTASES;
D O I
10.1016/j.mric.2016.06.003
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The Response Assessment in Neuro-Oncology (RANO) Working Group is an international multidisciplinary group whose goal is to improve response criteria and define endpoints for neuro-oncology trials. The RANO criteria for high-grade gliomas attempt to address the issues of pseudoprogression, pseudoresponse, and nonenhancing tumor progression. Incorporation of advanced MR imaging may eventually help improve the ability of these criteria to better define enhancing and nonenhancing disease. The RANO group has also developed criteria for neurologic response and evaluation of patients receiving immunologic therapies. RANO criteria have been developed for brain metastases and are in progress for meningiomas, leptomeningeal disease, spinal tumors, and pediatric tumors.
引用
收藏
页码:705 / +
页数:15
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