Longitudinal Changes in Prefrontal Cortex Activation Underlie Declines in Adolescent Risk Taking

被引：91
作者：
Qu, Yang [1 ]
Galvan, Adriana [3 ,4 ]
Fuligni, Andrew J. [3 ,5 ]
Lieberman, Matthew D. [3 ,5 ]
Telzer, Eva H. [1 ,2 ]
机构：
[1] Univ Illinois, Dept Psychol, Urbana, IL 61820 USA
[2] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61820 USA
[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA
[5] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
来源：
JOURNAL OF NEUROSCIENCE | 2015年 / 35卷 / 32期
基金：
美国国家科学基金会;
关键词：
adolescence; fMRI; prefrontal cortex; risk taking; INNER-CITY ADOLESCENTS; TASK BART; RESPONSE-INHIBITION; COGNITIVE CONTROL; DECISION-MAKING; BRAIN ACTIVITY; BEHAVIOR; FMRI; AGE; SENSITIVITY;
D O I：
10.1523/JNEUROSCI.1553-15.2015
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Adolescence is a critical developmental phase during which risk-taking behaviors increase across a variety of species, raising the importance of understanding how brain changes contribute to such behaviors. While the prefrontal cortex is thought to influence adolescent risk taking, the specific ways in which it functions are unclear. Using longitudinal functional magnetic resonance imaging in human adolescents, we found that ventrolateral prefrontal cortex (VLPFC) activation decreased during an experimental risk-taking task over time, with greater declines in VLPFC associated with greater declines in self-reported risky behavior. Furthermore, greater decreases in functional coupling between the medial prefrontal cortex (MPFC) and ventral striatum over time were associated with decreases in self-reported risky behavior. Thus, disparate roles of the VLPFC and MPFC modulate longitudinal declines in adolescent risk taking.
引用
收藏
页码：11308 / 11314
页数：7
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