Association between KLK3 rs2735839 G/A Polymorphism and Serum PSA Levels in Japanese Men

被引：7

作者：

Nobata, Syunsuke ^{[2
]}

Hishida, Asahi ^{[1
]}

Naito, Mariko

Asai, Yatami

Mori, Atsuyoshi ^{[2
]}

Kuwabara, Mayumi ^{[2
]}

Katase, Shiro ^{[3
]}

Okada, Rieko

Morita, Emi

Kawai, Sayo

Hamajima, Nobuyuki

Wakai, Kenji

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Prevent Med, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Seirei Prevent Hlth Care Ctr, Hamamatsu, Shizuoka, Japan

[3] Seirei Hlth Support Ctr, Shizuoka, Japan

来源：

UROLOGIA INTERNATIONALIS | 2012年 / 89卷 / 01期

关键词：

Prostate-specific antigen; Kallikrein-related peptidase 3; Prostate cancer; Single nucleotide polymorphism; PROSTATE-SPECIFIC ANTIGEN; GENOME-WIDE ASSOCIATION; FOOD FREQUENCY QUESTIONNAIRE; SUSCEPTIBILITY LOCI; CANCER RISK; AMERICAN MEN; POPULATION; GENE; MORTALITY; OBESITY;

D O I：

10.1159/000332197

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To clarify the association of kallikrein-related peptidase 3 (KLK3) rs2735839 G/A polymorphism with serum prostate-specific antigen (PSA) levels in Japanese men. Methods: Subjects were participants of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study who visited the Seirei Preventive Health Care Center in Shizuoka, Japan. Among the 5,040 individuals aged 35-69 years who were enrolled in 2006-2007, serum PSA data were available for 2,323 male subjects without a past history of prostate cancer. The diagnostic criteria for PSA positivity was PSA >= 4.0 ng/ml. Genotyping of the KLK3 polymorphism was conducted by the polymerase chain reaction with the confronting two-pair primers (PCR-CTPP) method. Results: The mean +/- SD of PSA levels (mg/dl) were 1.54 +/- 1.73 for those with KLK3 rs2735839 GIG genotype, 1.34 +/- 1.33 for G/A, and 1.20 +/- 1.23 for A/A, which was significantly different (p < 0.0001). The age-adjusted odds ratios of PSA test positivity were 0.62 (95% confidence interval 0.41-0.94) for those with G/A + A/A relative to those with G/G. Conclusions: The present study revealed that the KLK3 rs2735839 G allele was significantly associated with higher serum PSA levels also in Japanese. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：39 / 44

页数：6

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