Thermo-triggered release of a Cys probe from the cavity of a water-soluble pillar[5]arene

被引：11
作者：
Chi, Xiaodong [1 ]
Wang, Pi [1 ]
Li, Yang [1 ]
Ji, Xiaofan [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 30期
关键词：
Pillararene; Hydrophobic interaction; Host-guest system; Supramolecular chemistry; RECOGNITION; CHEMISTRY; NETWORKS; BINDING;
D O I：
10.1016/j.tetlet.2015.06.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel [2]pseudorotaxane based on thermo-responsive water-soluble pillar[5]arene WP5 and Cys probe 1 was successfully prepared in water. This complex exhibited no responsiveness to Cys at room temperature due to its high stability that inhibited the interaction between probe 1 and Cys. However, the encapsulated 1 could be released from the cavity of WP5 upon heating, leading to the formation of 1-Cys adduct. Moreover, the probe could be used to monitor Cys with high sensitivity. Importantly, WP5, 1, and the [2]pseudorotaxane WP5 superset of 1 showed excellent biocompatibility, making the probe a very attractive candidate for biological applications. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4545 / 4548
页数：4
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