RIP Kinases Initiate Programmed Necrosis

被引：91

作者：

Galluzzi, Lorenzo ^{[1
,2
,3
]}

Kepp, Oliver ^{[1
,2
,3
]}

Kroemer, Guido ^{[1
,2
,3
]}

机构：

[1] INSERM, U848, F-94805 Villejuif, France

[2] Inst Gustave Roussy, F-94805 Villejuif, France

[3] Univ Paris 11, F-94270 Le Kremlin Bicetre, France

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2009年 / 1卷 / 01期

关键词：

D O I：

10.1093/jmcb/mjp007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently, the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death. Some mechanistic details, however, remain controversial.

引用

页码：8 / 10

页数：3

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