An Infant With Medulloepithelioma Successfully Treated by High-dose Chemotherapy Followed by Autologous Peripheral Blood Stem Cell Transplantation Without Radiotherapy

被引：7

作者：

Hayase, Tomomi ^{[1
]}

Morimoto, Akira ^{[1
]}

Kawahara, Yuta ^{[1
]}

Yagi, Masaki ^{[1
]}

Kanai, Nobuyuki ^{[2
]}

Nobusawa, Sumito ^{[4
]}

Hirato, Junko ^{[5
]}

Gomi, Akira ^{[3
]}

机构：

[1] Jichi Med Univ, Sch Med, Jichi Childrens Med Ctr Tochigi, Dept Pediat, Shimotsuke, Tochigi 3290498, Japan

[2] Jichi Med Univ, Sch Med, Diagnost Pathol, Shimotsuke, Tochigi 3290498, Japan

[3] Jichi Med Univ, Sch Med, Jichi Childrens Med Ctr Tochigi, Dept Pediat Neurosurg, Shimotsuke, Tochigi 3290498, Japan

[4] Gunma Univ, Grad Sch Med, Dept Human Pathol, Maebashi, Gunma 371, Japan

[5] Gunma Univ Hosp, Dept Pathol, Maebashi, Gunma, Japan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2015年 / 37卷 / 06期

关键词：

medulloepithelioma; high-dose chemotherapy; autologous peripheral blood stem cell transplantation; radiotherapy; NERVOUS-SYSTEM MEDULLOEPITHELIOMA; MALIGNANT BRAIN-TUMORS; CEREBRAL MEDULLOEPITHELIOMA; AMPLIFICATION; COMPRISE; RESCUE;

D O I：

10.1097/MPH.0000000000000381

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Medulloepithelioma of the central nervous system (CNS) is a rare primitive neuroectodermal tumor characterized by highly malignant behavior occurring in early childhood. Few cases have been reported and optimal management remains unknown. Here, we report a case of CNS medulloepithelioma successfully treated with high-dose chemotherapy (HDCTX) followed by autologous stem cell transplantation (auto-SCT) without radiotherapy. At the last follow-up, 3.0 years after onset, the patient was alive with no sign of relapse and normal development. To the best of our knowledge, this is the first reported case of long-term survival of CNS medulloepithelioma treated by HDCTX/auto-PBSCT without radiotherapy.

引用

页码：e394 / e398

页数：5

共 20 条

[1]

Darzy Ken H., 2009, V15, P1, DOI 10.1159/000207607

[2] Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: A report from the children's cancer group [J].

Geyer, JR ;

Sposto, R ;

Jennings, M ;

Boyett, JM ;

Axtell, RA ;

Breiger, D ;

Broxson, E ;

Donahue, B ;

Finlay, JL ;

Goldwein, LW ;

Heier, LA ;

Johnson, D ;

Mazewski, C ;

Miller, DC ;

Packer, R ;

Puccetti, D ;

Radcliffe, J ;

Tao, ML ;

Shiminski-Maher, T .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (30) :7621-7631

[3] The therapy of infantile malignant brain tumors: Current status? [J].

Kalifa, C ;

Grill, J .

JOURNAL OF NEURO-ONCOLOGY, 2005, 75 (03) :279-285

[4] Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity [J].

Korshunov, Andrey ;

Sturm, Dominik ;

Ryzhova, Marina ;

Hovestadt, Volker ;

Gessi, Marco ;

Jones, David T. W. ;

Remke, Marc ;

Northcott, Paul ;

Perry, Arie ;

Picard, Daniel ;

Rosenblum, Marc ;

Antonelli, Manila ;

Aronica, Eleonora ;

Schueller, Ulrich ;

Hasselblatt, Martin ;

Woehrer, Adelheid ;

Zheludkova, Olga ;

Kumirova, Ella ;

Puget, Stephanie ;

Taylor, Michael D. ;

Giangaspero, Felice ;

Collins, V. Peter ;

von Deimling, Andreas ;

Lichter, Peter ;

Huang, Annie ;

Pietsch, Torsten ;

Pfister, Stefan M. ;

Kool, Marcel .

ACTA NEUROPATHOLOGICA, 2014, 128 (02) :279-289

[5] CEREBRAL MEDULLOEPITHELIOMA - HISTOLOGICAL AND HISTOCHEMICAL STUDY OF A CASE [J].

LOLOVA, I ;

BOJINOV, S ;

IVANOVA, A ;

CHRISTOV, V .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1972, 15 (02) :173-&

[6] Myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for childhood central nervous system tumors [J].

Marachelian, A. ;

Butturini, A. ;

Finlay, J. .

BONE MARROW TRANSPLANTATION, 2008, 41 (02) :167-172

[7] Cerebral medulloepithelioma with long survival [J].

Matsumoto, Masato ;

Horiuchi, Kazuomi ;

Sato, Taku ;

Oinuma, Masahiro ;

Sakuma, Jun ;

Suzuki, Kyouichi ;

Sasaki, Tatsuya ;

Kodama, Namio ;

Watanabe, Kazuo ;

Suzuki, Toshimitsu .

NEUROLOGIA MEDICO-CHIRURGICA, 2007, 47 (09) :428-433

[8] Long-term survival in a child with a central nervous system medulloepithelioma [J].

Moftakhar, Parham ;

Fan, Xuemo ;

Hurvitz, Carole H. ;

Black, Keith L. ;

Danielpour, Moise .

JOURNAL OF NEUROSURGERY-PEDIATRICS, 2008, 2 (05) :339-345

[9] Central nervous system medulloepithelioma: A series of eight cases including two arising in the pons [J].

Molloy, PT ;

Yachnis, AT ;

Rorke, LB ;

Dattilo, JJ ;

Needle, MN ;

Millar, WS ;

Goldwein, JW ;

Sutton, LN ;

Phillips, PC .

JOURNAL OF NEUROSURGERY, 1996, 84 (03) :430-436

[10] Curative Treatment for Central Nervous System Medulloepithelioma despite Residual Disease after Resection Report of Two Cases Treated According to the GPHO Protocol HIT 2000 and Review of the Literature [J].

Mueller, Klaus ;

Zwiener, Isabella ;

Welker, Helmut ;

Maass, Eberhard ;

Bongartz, Rudolf ;

Berthold, Frank ;

Pietsch, Torsten ;

Warmuth-Metz, Monika ;

von Bueren, Andre ;

Rutkowski, Stefan .

STRAHLENTHERAPIE UND ONKOLOGIE, 2011, 187 (11) :757-762

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