α-Tocopherol attenuates NFκB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior

被引：53

作者：

Godbout, JP

Berg, GM

Krzyszton, C

Johnson, RW

机构：

[1] Univ Illinois, Div Nutr Sci, Anim Sci Lab 390, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 169卷 / 1-2期

关键词：

brain; lipopolysaccharide; NF kappa B; Cytokines; alpha-tocopherol; mice;

D O I：

10.1016/j.jneuroim.2005.08.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study was conducted to determine if alpha-tocopherol facilitates recovery from lipopolysaccharide (LPS)-induced sickness behavior through a NF kappa B-dependent mechanism. In the first study, 3 daily intraperitoneal (i.p.) injections of a-tocopherol (20 mg) improved recovery from sickness behavior induced by i.p. injected LPS. Furthermore, alpha-tocopherol pretreatment attenuated LPS-activated NF kappa B and proinflammatory cytokine production in brain. In addition, inhibiting NF kappa B activity in the brain specifically by ICV injection of a NF kappa B decoy prior to LPS, significantly accelerated recovery from LPS-induced sickness behavior. Taken together, these data indicate alpha-tocopherol modulates sickness behavior and inflammatory cytokine production in the brain through an NF kappa B-dependent pathway. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：97 / 105

页数：9

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[1] Inhibition of nuclear factor-κB activation by IRFI 042, protects against endotoxin-induced shock (Publication with Expression of Concern. See MAR, 2023) [J].